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extract to retain the normalization of the hepatic tissue as 13. Buriti FC, Cardarelli HR, Filisetti TM, Saad SM. Synbiotic potential
neither necrosis nor fatty accumulation were observed and of fresh cream cheese supplemented with inulin and Lactobacillus
the central vein clearly appeared. [69] paracasei in co-culture with Streptococcus thermophilus. Food Chem
2007;104:1605-10.
14. Kaur N, Gupta AK. Applications of inulin and oligofructose in health
In conclusion, the current data indicated the efficacy of chicory and nutrition. J Biosci 2002;27:703-14.
extract (IN) supplementation as an anti-HCC in addition to 15. Toyama T, Nakamura H, Harano Y, Yamauchi N, Morita A, Kirishima T,
Minami M, Itoh Y, Okanoue T. PPARalpha ligands activate antioxidant
its ability as a chemo-sensitizer for CIS treatment. This is enzymes and suppress hepatic fi brosis in rats. Biochem Biophys Res
mediated by intracellular pathways, involving improvement Commun 2004;324:697-704.
of the alterations in liver functions, as well as other aspects 16. Yilmaz HR, Iraz M, Sogut S, Ozyurt H, Yildirim Z, Akyol O,
of HCC, the suppression of oxidative stress, and modulation Gergerlioglu S. The effects of erdostiene on the activity of some
metabolic enzymes during cisplatin-induced nephrotoxicity in rats.
of antioxidant defense mechanisms. Thus, supplementation Pharmacol Res 2004;50:287-90.
with chicory extract may help in the safe application of cancer 17. Rault-Nania MH, Demougeot C, Gueux E, Berthelot A, Dzimira S,
technology in medicine, as well as in many other aspects of Rayssiguier Y, Rock E, Mazur A. Inulin supplementation prevents high
fructose diet-induced hypertension in rats. Clin Nutr 2008;27:276-82.
everyday life. Fractionation guided evaluation could help 18. Frings CS, Fendley TW, Dunn RT, Queen CA. Improved determination
in the development of an ideal anticancer treatment in the of total serum lipids by the sulfo-phospho-vanillin reaction. Clin Chem
near future. 1972;18:673-4.
19. Kayamori Y, Hatsuyama H, Tsujioka T, Nasu M, Katayama Y. Endpoint
colorimetric method for assaying total cholesterol in serum with
Financial support and sponsorship cholesterol dehydrogenase. Clin Chem 1999;45:2158-63.
Nil. 20. Wahlefeld AW. Determination of serum triglycerides level. In:
Bergmeyer H, editor. Methods of Enzymatic Analysis. New York:
Confl ict of interest Academic Press; 1974. p. 1831-5.
There is no conflict of interest. 21. Naito HK, Kwak YS. The evaluation of a new high density lipoprotein
cholesterol (HDL-C) technology: selective separation of lipoproteins
by magnetic precipitation. Clin Chem 1995;41:S135.
REFERENCES 22. Ahmadi SA, Boroumand MA, Gohari-Moghaddam K, Tajik P, Dibaj SM.
The impact of low serum triglyceride on LDL-cholesterol estimation.
Arch Iran Med 2008;11:318-21.
1. Zong A, Cao H, Wang F. Anticancer polysaccharides from
natural resources: a review of recent research. Carbohydr Polym 23. Satheesh MA, Pari L. Effect of pterostilbene on lipids and lipid profi les
2012;90:1395-410. in streptozotocin-nicotinamide induced type 2 diabetes mellitus. J Appl
2. Thoppil RJ, Bishayee A. Terpenoids as potential chemopreventive and Biomed 2008;6:31-7.
thera-peutic agents in liver cancer. World J Hepatol 2011;3:228-49. 24. Acosta AA. Direct immunoenzymatic determination of AFP in serum
or plasma. J Clin Immunoassays 1983;6:41.
3. Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in 25. Gornall AG, Bardawill CJ, David MM. Determination of serum protein
HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer by means of the biuret reaction. J Biol Chem 1949;177:751-66.
2013;13:123-35. 26. Doumas BT, Watson WA, Biggs HG. Albumin standards and the
4. Qin W, Liu NN, Wang L, Zhou M, Ren H, Bugnard E, Liu JL, Zhang LH, measurement of serum albumin with bromcresol green. Clin Chim Acta
Vendôme J, Hu JS, Xi XG. Characterization of biochemical properties 1971;31:87-96.
of Bacillus subtilis RecQ helicase. J Bacteriol 2014;196:4216-28. 27. Walter MI, Gerade HW. An ultra micromethod for the determination
5. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of conjugated and total bilirubin in serum or plasma. Microchem J
of cancer: metabolic reprogramming fuels cell growth and proliferation. 1970;15:231-43.
Cell Metab 2008;7:11-20. 28. Young DS. Effects of Drugs on Clinical Laboratory Tests. 4th ed.
6. Bauer JH, Goupil S, Garber GB, Helfand SL. An accelerated assay for Washington, DC: AACC Press; 2001.
the identifi cation of lifespan-extending interventions in Drosophila 29. Belfi eld A, Goldberg DM. Normal ranges and diagnostic value of serum
melanogaster. Proc Natl Acad Sci U S A 2004;101:12980-5. 5’nucleotidase and alkaline phosphatase activities in infancy. Arch Dis
7. Jamshidzadeh A, Khoshnood MJ, Dehghani Z, Niknahad H. Child 1971;46:842-6.
Hepatoprotective activity of Cichorium intybus L. leaves extract against 30. Tietz NW. Clinical Guide to Laboratory Tests. 3 ed. Philadelphia, PA:
rd
carbon tetrachloride induced toxicity. Iran J Pharm Res 2006;5:41-6. WB Saunders Company; 1995.
8. Kim M, Shin HK. The water-soluble extract of chicory reduces glucose 31. Goldman R, Kaplan NO, Hall TC. Lactic dehydrogenase in human
uptake from the perfused jejunum in rats. J Nutr 1996;126:2236-42. neoplastic tissues. Cancer Res 1964;24:389-99.
9. Roberfroid MB, Cumps J, Devogelaer JP. Dietary chicory inulin 32. Drury RA, Wallington EA, Cancerson R. Carlton’s Histopathological
increases whole-body bone mineral density in growing male rats. J Nutr Techniques. 4th ed. Oxford, UK: Oxford University Press; 1976.
2002;132:3599-602. 33. Sheehan D, Hrapchak B. Theory and Practice of Histotechnology. 2nd ed.
10. Reddy BS, Hamid R, Rao CV. Effect of dietary oligofructose and inulin Ohio: Battelle Press; 1980. p. 189-90.
on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 34. Waller RA, Duncan DB. A Bayes rule for the symmetric multiple
1997;18:1371-4. comparison problems. J Am Stat Assoc 1969;64:1484-503.
11. Wada T, Sugatani J, Terada E, Ohguchi M, Miwa M. Physicochemical 35. Chen B, Ning M, Yang G. Effect of paeonol on antioxidant and
characterization and biological effects of inulin enzymatically immune regulatory activity in hepatocellular carcinoma rats. Molecules
synthesized from sucrose. J Agric Food Chem 2005;53:1246-53. 2012;17:4672-83.
12. Roberfroid MB. Inulin-type fructans: functional food ingredients. J Nutr 36. Guyton KZ, Kensler TW. Oxidative mechanisms in carcinogenesis. Br
2007;137:S2493-502. Med Bull 1993;49:523-44.

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