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Figure 2: Photomicrographs of liver sections stained with Masson’s trichrome
staining (×100). (C) Liver section of control rats, fi brosis, and collagen fi bers
could not be seen; (HCC) liver section of HCC rat treated with thioacetamide,
increased fi brosis, and blue collagen fi bers are seen among hepatocytes and
central vein; (HCC + CIS) liver section of HCC rat treated with CIS, strands of blue
collagen are less seen among hepatocytes; (HCC + IN) liver section of HCC rat
that received IN, similar to the control rat group; (HCC + CIS + IN) liver section of
HCC rat treated with both CIS + IN, blue collagen fi bers among hepatocytes are
less seen. C: control; IN: inulin; CIS: cisplatin; HCC: hepatocellular carcinoma;
CV: central vein; white arrow: a curved short arrow on the fi gure indicating
blood sinusoids

decrease in the HDL fraction and an enormous increase in
the VLDL and LDL fractions through resulting increase lipid
peroxidation (LPO) during oxidative stress. Furthermore,
[44]
albumin in the human body transports essential fatty acids
from adipose tissue, otherwise known as fat, to muscle tissue;
it is made by the liver. Consequently, decreased albumin
levels may be associated with liver disease. Moreover, the
[45]
increase in the level of AFP in HCC rats indicates an HCC.
[46]
It was reported that elevated serum concentrations of AFP
can be observed in rats due to exposure to hepatotoxic
agents or hepatocarcinogens and are frequently associated
with HCC. Its serum concentration can be used to confirm
[47]
hepatocarcinoma and the diagnosis of tumor response to
Figure 1: Photomicrographs of liver sections stained with hematoxylin and therapy. More than 90% of patients with hepatitis, cirrhosis,
eosin (HE, left row ×100, right row ×400). (C) Control rat showing normal and hepatic cancer have increased serum AFP levels. [47]
hepatocytes architecture; (HCC) liver of HCC rat treated with CIS, showing
damage hepatocytes with lymphocyte cells infi ltration; (HCC + CIS) liver of HCC rat
treated with CIS showing congested central vein and blood sinusoids; (HCC + IN) Moreover, the observed alterations in serum AST, ALT, ALP, CK,
liver of HCC rat that received IN similar to control group; (HCC + CIS + IN) liver and LDH activity and total bilirubin levels are good indicators
of HCC treated with both CIS + IN showing maintained hepatic architecture,
with minimal damage. C: control; IN: inulin; CIS: cisplatin; HCC: hepatocellular for hepatic injury resulting from cellular leakage and the loss
carcinoma; CV: central vein; HP: hepatocytes; BS: blood sinusoids; VHP: vascular in functional integrity of the cell membrane in liver. Cellular
[48]
hepatocytes; DBS: degenerated blood sinusoids; PV: portal vein; H: hepatocytes; damages are identified by increases in serum ALP, ALT, and
white arrow: blood sinusoids; arrowhead: Kupffer cells; black arrow: endothelial
cells; *Lymphocytic cell infi ltration AST levels in that these enzymes are in the cytoplasm and

Hepatoma Research | Volume 1 | Issue 3 | October 15, 2015 151