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Bilovol Arterial hypertension and type 2 diabetes progression

correlated with increased concentrations of TG and essential to etiology of cardiometabolic disorders.
glucose (r = 0.415, P = 0.001; r = 0,042, P = 0.014, Despite these findings, research directions continue
respectively). to focus on obesity as the essential therapeutic target
for reducing the risk of metabolic syndrome, T2DM,
Finally, both AH and AH/T2DM patients experienced and associated cardiovascular complications. Given
significant increases in IL-1β levels when compared the widespread incidence of comorbid hypertension in
to controls. The most pronounced differences were diabetic patients, identifying new markers responsible
observed in patients with both AH and T2DM (P = for increased blood pressure during insulin resistance
0.008). These results have been associated with is a paramount research concern.
presumptive stimulation of acute-phase protein
syntheses occurring as a result of AH and T2DM. Authors’ contributions
Additionally, ІL-4 activities were increased and positive O. Bilovol contributed solely to this paper.
correlations were observed between IL-4 and IL-1β (r
= 0.42, P < 0.01) and IL-6 (r = 0.44, P < 0.01). These Financial support and sponsorship
data suggested that compensatory signaling activities
were occurring, given that IL-4 has been regulated to None.
promote stabilization of inflammation. The regularity
in which comorbid AH and T2DM experienced Conflicts of interest
alterations in metabolic signaling factors emphasized There are no conflicts of interest.
the systematic and patterned etiologies of metabolic
disorders. Negative correlations between IL-6 and both Patient consent
omentin and adiponectin (r = -0.46, P < 0.01; r = -0.42, All involved patients gave their consent forms.
P < 0.01, respectively) were observed. These findings
were consistent with previous studies indicating that Ethics approval
IL-6 regulated adipokine production. [18,21,22] The study protocol was approved by the Local Ethics
Committee of the Kharkov National Medical University
DISCUSSION and was performed in accordance to the Declaration
of Helsinki.
Presence of comorbid hypertension and type 2
diabetes is often associated with underlying metabolic
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