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Bilovol. Vessel Plus 2017;1:22-8 Vessel Plus
DOI: 10.20517/2574-1209.2016.11
www.vpjournal.net
Original Article Open Access

Predictors of hormonal and metabolic

disorders of arterial hypertension and type

2 diabetes mellitus comorbidity

Oleksandr Bilovol

Department of Clinical Pharmacology, Kharkiv National Medical University, 61000 Kharkiv, Ukraine.
Correspondence to: Prof. Oleksandr Bilovol, Department of Clinical Pharmacology, Kharkiv National Medical University, 2A Malaya Avenue,
61000 Kharkiv, Ukraine. E-mail: Bilovol.Oleksandr@rada.gov.ua

How to cite this article: Bilovol O. Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity.
Vessel Plus 2017;1:22-8.
ABSTRACT

Article history: Aim: These experiments studied adipokine and interleukin imbalances during the
Received: 26-10-2016 development and progression of metabolic disorders in patients with arterial hypertension
Accepted: 02-03-2017 (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II
Published: 31-03-2017 second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The
cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients
with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis
Key words: factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β, IL-4, and IL-6
Hypertension, were measured. Lipid and carbohydrate metabolism rates were assessed. Results: Peak
type 2 diabetes mellitus, homeostatic model assessment for insulin resistance (HOMA-IR) index values, as well as
adipokines, circulating insulin and CRP levels, were observed in group 2. Reduced adiponectin levels
interleukins
negatively correlated with HOMA-IR indices (r = -0.52, P < 0.05), triglycerides (r = -0.52,
P < 0.05), glucose levels (r = -0.44, P < 0.05), body mass indices (r = -0.44, P < 0.05), and
HbA1c levels (r = -0.57, P < 0.01). Group 2 patients demonstrated low omentin levels and
high resistin and TNF-α levels. Negative correlations between IL-6 and both omentin and
adiponectin (r = -0.46, P < 0.01; r = -0.42, P < 0.01, respectively) were observed. Conclusion:
A novel pathogenic link was demonstrated between metabolic disorders, adipokines, and
pro-inflammatory IL-6 levels as negative regulators of comorbid AH and T2DM.

INTRODUCTION 72.5% in women). Sur et al. in 2010 reported that
[2]
[3]
more than 3 million people in Romania are hypertensive.
Arterial hypertension (AH) is an important public In 2009, one-fifth of the adult Danish population was
health challenge in both economically developing and hypertensive. Hypertension affects nearly 75 million
[4]
developed countries. The reported prevalence of AH adults in the USA and is a major risk factor for myocardial
[1]
has varied globally; the lowest prevalences was found infarction, ischemic stroke, chronic kidney disease, and
in rural India (3.4% in men and 6.8% in women) and vascular disease. According to an analysis of American
the highest was observed in Poland (68.9% in men and data from the Nationwide Emergency Department
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