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Page 12 of 27                            Tian et al. Soft Sci 2023;3:30  https://dx.doi.org/10.20517/ss.2023.21

               Evaluation parameters
               Flexible pressure and temperature e-skin sensors are supposed to possess excellent performance, including
               compliance, robustness, and timeliness. Therefore, based on several kinds of combined mechanisms,
               quantitative comparison can be realized since the output signals containing data information can be read
               out in numerical form. The main quantitative parameters comprise sensitivity, range, response time, and
                      [7]
               stability .

               The sensitivity parameters are the most essential for the characterization of entire sensing systems. Both
                                                                     -1
               resistive and capacitive sensors have similar forms and units (Pa ) for their sensitivity parameters, as shown
               in Equations (1), (2), and (7). However, the unit of sensitivity can be expressed in V/Pa or V/℃ for sensors
               based on potential mechanisms due to a linear relationship between input stimuli and output response, as
               shown in Equations (3), (4), and (5) [62,69] . Most sensing systems exhibit non-linear stimuli-response changes.
               Hence, non-linear sensing curves are often segmented to calculate sensitivities for different scopes of
               stimuli. With the pressure or temperature increasing, sensitivity parameters decrease for most systems.

               The sensing range defines the maximum and minimum ranges that a sensor system can measure under
               normal conditions. Maximum and minimum sensing data originate from sensors in a limited state, so their
               accuracy is doubtful. For e-skin sensors with pressure and temperature sensing, the focus is primarily on
               tactile sensation and body temperature, such as pulse, respiration, gesture, and motion. From this point of
               view, the sensitivity is more significant than the sensing range, as e-skin sensors have a relatively narrow
               desired sensing range.

               The response time is also a vital evaluation parameter, which implies how rapidly the output of the sensor
               changes with the varying external stimuli. It can be calculated by measuring the time difference between the
                                                                                  [7]
               input time of stimuli and the stable (or 90% position) time of output response . Stability, symbolizing the
               robustness of the sensing system, can be measured by the shifting of output response after thousands of
               cycles of external stimuli. The more cycles the sensors bear, the less irreversible deformation occurs,
               resulting in better robustness.

               MULTIPLE MECHANISM INTEGRATION AND STRUCTURAL DESIGN OF PRESSURE AND
               TEMPERATURE SENSORS
               In a brief review, we have listed details about material selection and basic mechanisms for signal detection
               of pressure and temperature. However, systematic design and construction are undoubtedly important, as it
               integrates multiple materials, mechanisms, and structures to achieve composite sensing functions, and even
               manufacturing methods are briefly considered. In regard to pressure and temperature sensing, two
               strategies are adopted so as to design highly-integrated pressure and temperature sensors, respectively,
               new structures with traditional materials and new materials with traditional structures. Actually,
               common structures used in sensing systems include multilayer films [23,24,27,71,72] , porous structures [11,15] ,
               multipixel , 3D structures , nanofibers , pyramid (pyramid-like) microstructures [14,23,75] , and serpentine
                                      [11]
                        [73]
                                                  [74]
               configurations [45,76] . Herein, we start with the integration of sensing mechanisms dividing flexible pressure
                                                                                              [3]
               and temperature sensors into two categories, namely, the same and different output signals . Because of
               extensive applications of electric outputs and decoupling-free, sensing systems with different electric output
               signals (DEOS) are mainly concerned and presented in detail, while sensing systems with the same electric
               output signals (SEOS) are introduced briefly. Typically, some pressure and temperature (or more physical
               and biochemical sensing functions) sensor devices based on the DEOS system and the SEOS system are
               compared in Table 2.
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