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Page 8 of 14 Nakamoto et al. Plast Aesthet Res 2024;11:54 https://dx.doi.org/10.20517/2347-9264.2024.82

Table 2. Blood glucose level (mg/dL) for each sheep from Day 0 to Day 14

Day 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Sheep1 70 59 59 57 60 55 55 68 68 69 58 57 75 56 61
Sheep2 73 70 63 59 60 58 77 86 77 68 62 49 69 77 73

Sheep3 63 66 71 81 39 67 63 56 77 61 65 66 63 62 70
Sheep4 68 64 70 66 72 66 57 52 66 62 60 63 64 54 57

Table 3. Mean arterial blood pressure (mmHg) for each sheep from Day 0 to Day 14

Day 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Sheep1 94 93 91 99 106 97 102 97 101 111 94 101 96 101 93

Sheep2 105 102 115 104 115 115 116 114 104 111 111 120 119 112 112
Sheep3 81 90 101 94 87 96 78 77 95 93 86 91 91 86 95
Sheep4 95 100 107 104 107 90 90 100 90 100 105 94 99 93 95

Table 4. Heart rate (min) for each sheep from Day 0 to Day 14

Day 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Sheep1 65 71 73 80 73 86 69 92 95 77 82 87 81 79 61
Sheep2 55 60 63 74 70 72 56 74 56 65 72 62 86 57 58
Sheep3 68 69 100 110 92 100 73 63 101 91 96 99 95 63 99
Sheep4 76 88 89 88 85 88 105 102 103 100 102 72 97 98 95

of beta-blockers with angiogenetic agents could further accelerate the wound epithelialization rate.

[16]
It has previously been shown that beta-blockers suppress inflammation . Therefore, beta-blockers could offset the increased blood flow by suppressing
inflammation, even if blood flow was increased by neovascularization. However, in the present study, the numbers of neutrophils and macrophages in the
wounds were comparable, suggesting that the beta-blocker timolol failed to modulate inflammation. Future studies should correlate the number of neovascular

vessels to the severity of local inflammation to clarify the hypothesis.