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been shown recently. [50] Neuroendoscopic treatment, mortality was the neurologic condition of the patient
when compared to stereotactic aspiration, has an at the time of admission. Here, we found mortality
additional advantage of more complete drainage and was very high in brain abscess with low GCS score on
lavage. [51] admission [Tables 7 and 8]. Landriel et al. [39] revealed
that age, immunosuppression and hematogenous
Many authors recommended craniotomy and excision spread were all associated with poor outcomes.
for abscesses that enlarge after 2 weeks of antibiotic
therapy or that fail to shrink after 3-4 weeks of In conclusion, predisposing factors were seen in nearly
antibiotics. [1,6,7,45] Craniotomy is also recommended half of the cases. In most of the cases, pus culture did
for multiloculated abscesses and larger lesions with not yield causative organisms. From this series, we
significant mass effect that are superficial and located see that in “chronic abscess group” pyogenic abscess
in noneloquent regions of the brain. A few authors also were the commonest followed by tuberculus abscess
recommended excision of abscesses in the cerebellum, but possibilities of other causes (i.e. fungal) should
where recurrent pus collection following aspiration can not be overlooked. Mortality due to brain abscess
lead to precipitous neurological worsening. [26] There was not directly related to surgical intervention but
are certain advantages to excision of a brain abscess on admission GCS has a significant association with
in an otherwise neurologically intact patient. The the mortality. Like other diseases, we can state early
risk of repeated collection of pus is almost completely diagnosis and optimum follow-up, and timely surgical
eliminated, and hence the expense involved in repeated interventions are the keys in the management of brain
imaging is saved. The duration of hospitalization abscess.
is also reduced. Furthermore, in patients with an
otogenic brain abscess, the disease in the middle ear REFERENCES
can also be surgically treated at the same sitting or
soon thereafter. [18] This also reduces the likelihood 1. Bernardini GL. Diagnosis and management of brain abscess and
of recurrence of the abscess. Abscess resulting from 2. subdural empyema. Curr Neurol Neurosci Rep 2004;4:448‑56.
Wilson HL, Kennedy KJ. Scedosporium apiospermum brain
fistulous communication, example, trauma and abscesses in an immunocompetent man with silicosis. Med Mycol
congenital dermal sinus, require excision of infected Case Rep 2013;2:75‑8.
granulation tissue and closure of the fistula. Abscess 3. Ansari MK, Jha S. Tuberculous brain abscess in an immunocompetent
localized to one lobe and contiguous to primary source 4. adolescent. J Nat Sci Biol Med 2014;5:170‑2.
Zhang C, Hu L, Wu X, Hu G, Ding X, Lu Y. A retrospective study
that is, frontal sinus osteomyelitis, is better treated with on the aetiology, management, and outcome of brain abscess in an
excision along with the primary focus. Posttraumatic 11‑year, single‑centre study from China. BMC Infect Dis 2014;14:311.
abscess containing foreign body or contaminated 5. Loftus CM, Osenbach RK, Biller J. Diagnosis and management of
retained bone fragments requires excision to prevent brain abscess. In: Wilkins RH, Rengachary SS, editors. Neurosurgery.
2nd ed. New York: McGraw‑Hill; 1996. p. 3285‑98.
recurrence. [8,46] Abscesses containing gas are resistant to 6. Sharma BS, Gupta SK, Khosla VK. Current concepts in
antibiotics and are better treated with excision. [52] Large the management of pyogenic brain abscess. Neurol India
superficial abscesses resistant to multiple aspirations 2000;48:105‑11.
and not showing volume reduction because of adhesions 7. Takeshita M, Kagawa M, Yonetani H, Izawa M, Yato S, Nakanishi T,
to the dura, due to large brain surface area should Monma K. Risk factors for brain abscess in patients with congenital
cyanotic heart disease. Neurol Med Chir (Tokyo) 1992;32:667‑70.
be excised for cure. Multiloculated actinomycotic 8. Joshi SM, Devkota UP. The management of brain abscess in a
and nocardial abscess may need excision as simple developing country: are the results any different? Br J Neurosurg
aspiration may prove inadequate. [53] Excision reduces 1998;12:325‑8.
the incidence of seizures and prevents recurrence. 9. Britt RH. Brain abscess. In: Wilkins RH, Rengachary SS, editors.
Neurosurgery. New York: McGraw‑Hill; 1985. p. 1928‑56.
Abscess in cerebritis stage, deep-seated abscesses in 10. Loeffler JM, Bodmer T, Zimmerli W, Leib SL. Nocardial brain
eloquent areas and multiple abscesses are the situation abscess: observation of treatment strategies and outcome in
where excision should not be considered. [6] Switzerland from 1992 to 1999. Infection 2001;29:337‑41.
11. Malik S, Joshi SM, Kandoth PW, Vengsarkar US. Experience with
brain abscesses. Indian Pediatr 1994;31:661‑6.
The mortality rate in our study was 13.58% (22 cases). 12. Tseng JH, Tseng MY. Brain abscess in 142 patients: factors
Sixteen patients died in the immediate postoperative influencing outcome and mortality. Surg Neurol 2006;65:557‑62.
period from brain herniation with very high 13. de Louvois J, Gortavai P, Hurley R. Bacteriology of abscesses of the
ICP (15 cases), ARDS (2 cases), septicemia with central nervous system: a multicentre prospective study. Br Med J
1977;2:981‑4.
systemic inflammatory response, multiple organ 14. Townsend GC, Scheld WM. Infections of the central nervous system.
dysfunction (4 cases) and one patient died from acute Adv Intern Med 1998;43:403‑47.
pancreatitis after operation. The mortality rate shown 15. Engelhardt K, Kampfl A, Spiegel M, Pfausler B, Hausdorfer H,
here is similar to the rates observed by other authors, Schmutzhard E. Brain abscess due to Capnocytophaga species,
Actinomyces species, and Streptococcus intermedius in a patient
which range between 8% and 53%. [54] Manzar et al. [43] with cyanotic congenital heart disease. Eur J Clin Microbiol Infect
reported that the most important factors influencing Dis 2002;21:236‑7.
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