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Selvakumar et al. Hepatoma Res 2017;3:86-9 Hepatoma Research
DOI: 10.20517/2394-5079.2017.01
www.hrjournal.net
Case Report Open Access

First case report of inflammatory

myofibroblastic tumor of peritoneal cavity in

a living donor liver transplantation recipient

Naganathan Selvakumar , Parul Saboti , Sumaid Kaul , Subash Gupta 2
1
2
2
1 Liver Transplantation Surgery, Indraprasta Apollo Hospital, Sarita Vihar, New Delhi 110074, India.
2 Department of Pathology, Indraprasta Apollo Hospital, Sarita Vihar, New Delhi 110074, India.
Correspondence to: Dr. Naganathan Selvakumar, Liver Transplantation Surgery, Indraprasta Apollo Hospital, Sarita Vihar, New Delhi 110074, India.
E-mail: enselva1@gmail.com
How to cite this article: Selvakumar N, Saboti P, Kaul S, Gupta S. First case report of inflammatory myofibroblastic tumor of peritoneal cavity in a
living donor liver transplantation recipient. Hepatoma Res 2017;3:86-9.
ABSTRACT

Article history: Post-transplantation malignancies are well known complications after liver transplantation.
Received: 08-01-2017 Certain malignancies are more common in pediatric recipients than adults. Inflammatory
Accepted: 17-03-2017 myofibroblastic tumors (IMTs) are reactive neoplasms with miniscule malignant potential.
Published: 17-05-2017 IMTs are more common after hematopoietic stem cell transplantation. However, there is 1
case reported in the literature after deceased donor liver transplantation. The authors describe
Key words: a case of IMT after living donor liver transplantation. The patient was a 1-year-old girl who
Inflammatory myofibroblastic underwent living donor liver transplantation (LDLT) for decompensated cirrhosis secondary to
tumor, extra hepatic biliary atresia. Six months post LDLT routine ultrasonography revealed multiple
living donor liver transplantation, solid abdominal masses. Repeated biopsies were inconclusive. Hence surgical excision was
extrahepatic biliary atresia carried out. Histopathological examination revealed IMT. Immunohistochemistry was positive
for anaplastic-lymphoma kinase activity. Ceritinib, a tyrosine kinase inhibitor, was used as
adjuvant chemotherapy for 1 year. At 1.5 years (at the time of writing this paper) of follow-up,
the child was disease free on imaging (whole body positron emission tomography-computed
tomography). This will be the first case of IMT after LDLT to be reported in the literature.

INTRODUCTION in some reported cases. Lungs are the commonest
site however they can present anywhere in the body.
Post-transplantation malignancies are well known We describe a case of 6 months old female child who
complication of chronic immunosuppression. Certain was suffering from end stage liver disease secondary
malignancies are more common in pediatric recipients to extra-hepatic biliary atresia (EHBA). She underwent
than in adults. Literature review revealed that living donor liver transplantation (LDLT). Six months
inflammatory myofibroblastic tumors (IMTs) generally post liver transplantation she was found to have
occur 3 to 6 months post-transplantation and are more intra-abdominal tumors on routine ultrasonography
common after hematopoietic stem cell transplantation (USG). She underwent surgical excision of peritoneal
(HSCT). Epstein-Barr virus has been held responsible neoplasms. Histopathological examination (HPE)

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