Page 97 - Read Online
P. 97

Selvakumar et al.                                                                                                                                                                      IMT post LDLT-report of first case

           In  our  case,  multiple  preoperative  biopsies  were   Financial support and sponsorship
           not confirmatory and led to delay in treatment. Final   None.
           excision biopsy was subjected to extensive evaluation
           with IHC panel which included c-KIT, ALK, CD117, CD   Conflicts of interest
           45, CK-7, neuron specific enolase, chromogranin, alpha   There are no conflicts of interest.
           fetal protein, desmin, actin. The tumor in this case was
           negative for other IHC markers including those specific   Patient consent
           for hepatocellular  carcinoma, cholangiocarcinoma,   Patient consent was received.
           neuroendocrine  tumors,  gastrointestinal stromal
           tumors  and  lymphomas.  However,  the  tumor  had   Ethics approval
           classic characteristics of IMT along with positive IHC   Since it is not a study and just a report, ethical approval
           for anti-lymphoma kinase. Complete tumor excision is   is not needed as per our hospital policies.
           curative in most cases.  However recurrence at new
                                [7]
           sites can be prevalent. Ceritinibis a tyrosine kinase   REFERENCES
           inhibitor accepted for treating tumors positive for ALK.
                                                          [8]
           The patient was given ceritinib for 1 year. Follow-up   1.   Pillai  AA.  Management  of  de  novo  malignancies  after  liver
           with PET CT at 1 year revealed no recurrence. Hence   transplantation. Transplant Rev (Orlando) 2015;29:38-41.
           ceritinib  was discontinued.  At 2 years, the child  is   2.   Piselli P, Busnach G, Fratino L, Citterio F, Ettorre GM, De Paoli P,
           disease free with good graft function.                Serraino D; Immunosuppression and Cancer Study Group. De novo
                                                                 malignancies  after  organ transplantation:  focus on viral  infections.
                                                                 Curr Mol Med 2013;13:1217-27.
           In  conclusion:  (1)  although  IMTs  are  rare,  it  is  a   3.   Lykavieris  P,  Fabre  M,  Waguet  J,  Bernard  O.  Inflammatory
           serious  complication  after  liver  transplantation;  (2)   pseudotumor after liver transplantation. J Pediatr Gastroenterol Nutr
           only one case has been reported in the literature so   2000;31:309-12.
           far after liver transplantation that too after DDLT; (3)   4.   Bronzino P, Abbo L, Bagnasco F, Barisone P, Dezzani C, Genovese
           in this case report we have described the first case   AM,  Iannucci  P,  Ippoliti  M,  Sacchi  M,  Aimo  I.  Intra-abdominal
           of  IMT  after  LDLT;  (4)  definitive  histologic  evidence   inflammatory myofibroblastic pseudotumor: case report and review of
                                                                 the literature. G Chir 2005;26:362-4.
           is essential in their diagnosis and differentiation from   5.   Tufan  A,  Bahat  G.  Inflammatory  pseudotumors  after  stem  cell
           other malignant tumors; and (5) IHC based targeted    transplantation. Hematol Rep 2015;7:5848.
           therapy may be helpful as adjuvant.                6.   Lykavieris  P,  Fabre  M,  Waguet  J,  Bernard  O.  Inflammatory
                                                                 pseudotumor after liver transplantation. J Pediatr Gastroenterol Nutr
           Authors’ contributions                                2000;31:309-12.
           Doing  surgery  and  writing  of  this  manuscript:  N.   7.   Vroobel K, Judson I, Dainton M, McCormick A, Fisher C, Thway K.
           Selvakumar                                            ALK-positive  inflammatory  myofibroblastic  tumor  harboring  ALK
                                                                 gene rearrangement, occurring after allogeneic stem cell transplant in
           Preparing the slides for histopathology: P. Saboti    an adult male. Pathol Res Pract 2016;212:743-6.
           Reporting of HPE: S. Kaul                          8.   Chaudhary P. Mesenteric inflammatory myofibroblastic tumors. Ann
           Chief surgeon in charge of the case: S. Gupta         Gastroenterol 2015;28:49-54.






























                           Hepatoma Research ¦ Volume 3 ¦ May 17, 2017                                     89
   92   93   94   95   96   97   98   99   100   101   102