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cyaniding-3-O-β-glucopyranoside on AFB  and OTA-induced   REFERENCES
                                           1
          toxicity is likely to be attributed to its antioxidant power.
                                                              1.   Food and Agricultural Organization.   Food Nutrition and Agriculture.
          Previous studies showed that the aqueous extract of     Food for the Future. Rome: FAO; 1991.
          A. hybridus has a significant immune-stimulating effect   2.   Castegnaro M, Dcgregor D. Carcinogenic risk assessment of mycotoxins.
                                                                  Rev Med Vet 1998;149:671-8.
          and its stem extract has been credited with antimalarial   3.   Richard JL. Some major mycotoxins and their mycotoxicoses – An
          activity and these effects are attributed to the presence   overview. Int J Food Microbiol 2007;119:3-10.
          of amaranthine, isoamaranthine, hydroxycinnamates,   4.   Paterson RR, Lima N.     Toxicology of mycotoxins. EXS 2010;2:31-63.
          quercetin, kaempferol glycosides, amaranthoside, amaricin,   5.   World Health Organization. Basic Food Safety for Health Workers.
                                                                  Geneva: WHO; 1999.
          and stigmasterol glycoside.  These authors concluded   6.   MERCK (Medical Research Council).   Afl atoxin in peanut butter. Science
                                  [60]
          that the hepatoprotective activity of A. hybridus might be   in Africa.     Darmstadt: MERCK; 2006.
          due to antioxidant defence factors and phenolics might be   7.   Wagacha JM, Muthomi JW. Mycotoxin problem in Africa: current
          the main constituents responsible for the activity. Isolated   status, implications to food safety and health and possible management
                                                                  strategies. Int J Food Microbiol 2008;124:1-12.
          polyhydroxylated nerolidols which have antiradical and   8.   World Health Organization. Mycotoxins in African foods: implications
          reducing capacities and could act as antilipoperoxidants. [61]  to food safety and health. AFRO Food Safety Newsletter. Geneva: WHO;
                                                                  2006.
                                                              9.   van Egmond HP.     Mycotoxins: regulations, quality assurance and
          In conclusion, A. hybridus extract has a high content of total   reference materials. Food Addit Contam 1995;12:321-30.
          phenolic, total carotenoids, β-carotene, folic acid, linolenic,   10.  Müller G, Burkert B, Möller U, Diller R, Rohrmann B, Rosoner H,
          linoleic, palmitic, calcium, magnesium, iron, zinc, and   Köhler H. Ochratoxin A and some of its derivatives modulate radical
          selenium. AFB  or FB  alone or in combination induced toxic   formation of porcine blood monocytes and granulocytes. Toxicology
                      1
                           1
                                                                  2004;199:251-9.
          effects on rat hepatoma cells. However, a mixture of the two   11.  El-Nekeety AA,  El-Kholy  W, Abbas  NF,  Ebaid A, Amra  HA,
          mycotoxins was most potent. The H4IIE-luc cells showed a   Abdel-Wahhab MA. Effi cacy of royal jelly against the oxidative stress
          weak antagonistic effect when exposed to the mixture of the   of fumonisin in rats. Toxicon 2007;50:256-69.
          two mycotixins as compared to the single toxin exposures. The   12.  Abdel-Wahhab  MA,  Hassan  NS,  El-Kady AA,  Mohamed YA,
          viability of cells was decreased by increasing concentrations   El-Nekeety AA,  Mohamed  SR,  Sharaf  HA,  Mannaa  FA.  Red
                                                                  ginseng protects against afl atoxin B  and fumonisin-induced hepatic
          of mycotoxins. Moreover, the binary mycotoxin mixture   pre-cancerous lesions in rats. Food Chem Toxicol 2010;48:733-42.
                                                                                          1
          posed a significant threat to the treated hepatoma cell line   13.  Hassan  AM,  Hassan  NS,  Mohamed  SR El-Nekeety  AA,
                                                                                                  ,
          as indicated by the absence/appearance of new bands beside   Abdel-Wahhab MA. Aquilegia vulgaris L extract counteracts oxidative
                                                                  stress and cytotoxicity of fumonisin in rats. Toxicon 2010;56:8-18.
          the severe DNA damage. Combined treatment with A. hybridus   14.  Hassan AM, Abdel-Aziem SH, Abdel-Wahhab MA. Modulation of
          extract and mycotoxins resulted in significant improvement   DNA damage and alteration of gene expression during afl atoxicosis via
          in cell viability accompanied with a significant decrease in   dietary supplementation of Spirulina (Arthrospira) and whey protein
          DNA damage and genotoxic effects. This improvement was   concentrate. Ecotoxicol Environ Safety 2012;79:294-300.
          more pronounced in the individual toxin-treated cells and a   15.  Abdel-Aziem  SH,  El-Nekeety AA,  Barakat  IA,  Mohamed  IM,
          dose dependent manner of the extract.                   Abdel-Wahhab MA. Aquilegia vulgaris extract protects against the
                                                                  oxidative stress and the mutagenic effects of cadmium. Exp Toxicol
                                                                  Pathol 2011;63:337-44.
          Financial support and sponsorship                   16.  Abdel-Aziem  SH,  Hassan AM, Abdel-Wahhab  MA.  Dietary
          The Morogo Research Program gratefully acknowledges the   supplementation with whey protein and ginseng extract counteract the
          National Research Foundation of South Africa (Focus Area   oxidative stress and DNA damage in rats fed afl atoxins-contaminated
                                                                  diet. Mutat Res 2011;723:65-71.
          Grant FA2004050600064) and National Research Center,   17.  van der Walt AM, Ibrahim MI, Bezuidenhout C, Loots DT. Linolenic
          Cairo, Egypt Project No. 10070112 for financial support of   acid and folate in wild-growing African dark leafy vegetables (morogo).
          this study. Prof. Giesy was supported by the Canada Research   Public Health Nutr 2008;12:525-30.
          Chair program, a Visiting Distinguished Professorship in   18.  van der Walt AM, Loots DT, Ibrahim MI, Bezuidenhout C. Minerals,
                                                                  trace  elements  and  antioxidant  phytochemicals  in  wild African
          the Department of Biology and Chemistry and State Key   dark-green leafy vegetables (morogo). S Afr J Sci 2009;105:444-8.
          Laboratory in Marine Pollution, City University of Hong Kong,   19.  Gari JA. Plant Diversity, Sustainable Livelihoods and the HIV/AIDS Crisis.
          the 2012 “High Level Foreign Experts” (No. GDT20143200016)   A Joint Publication of the United Nations Development Program and the
          program, funded by the State Administration of Foreign   Food and Agriculture Organization; 2004. Available from: http://www.
                                                                  hivpolicy.org/Library/HPP000946.pdf. [Last accessed on 2015 Sep 16].
          Experts Affairs, the P.R. China to Nanjing University and   20.  Kähkönen MP, Hopia AI, Vurela HJ, Rauha J, Pihlaja K, Kujala T,
          the Einstein Professor Program of the Chinese Academy of   Heinonen M. Antioxidant activity of plant extracts containing phenolic
          Sciences.                                               compounds. J Agric Food Chem 1999;47:3954-62.
                                                              21.  Edwards EJ, Saint RE, Cobb AH. Is there a link between greening
                                                                  and light enhanced glycoalkaloid accumulation in potato (Solanum
          Confl ict of interest                                    tuberosum L.) tubers? J Food Sci Agric 1998;76:327-33.
          There is no conflict of interest.                   22.  Lakshiminarayana  R,  Raju  R,  Krishnakantha  TP,  Baskare  V.


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