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Zhu et al. Soft Sci 2024;4:21 Soft Science
DOI: 10.20517/ss.2024.01

Perspective Open Access

Electrolyte engineering in organic electrochemical

transistors for advanced electrophysiology

1,2
Yanlan Zhu , Xiaomin Xu 1,2,*
1
Institute of Materials Research, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055,
Guangdong, China.
2
Shenzhen Geim Graphene Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, Guangdong,
China.
* Correspondence to: Prof. Xiaomin Xu, Institute of Materials Research, Tsinghua Shenzhen International Graduate
School, Tsinghua University, No. 2279, Lishui Road, Nanshan District, Shenzhen 518055, Guangdong, China. E-mail:
xu.xiaomin@sz.tsinghua.edu.cn

How to cite this article: Zhu Y, Xu X. Electrolyte engineering in organic electrochemical transistors for advanced
electrophysiology. Soft Sci 2024;4:21. https://dx.doi.org/10.20517/ss.2024.01

Received: 28 Jan 2024 First Decision: 29 Mar 2024 Revised: 22 Apr 2024 Accepted: 30 Apr 2024 Published: 27 May 2024

Academic Editors: Sang Min Won, Zhifeng Ren Copy Editor: Dong-Li Li Production Editor: Dong-Li Li

Abstract
Electrophysiology is an indispensable tool in the early diagnosis of a wide range of diseases, making the precise,
continuous, and stable recording of electrophysiological signals critically important. Organic electrochemical
transistors stand out among various electrophysiological recording devices, offering a high signal-to-noise ratio due
to their intrinsic amplification capability. However, despite their inherent advantages, several challenges persist in
practical scenarios, such as the stability of wearable devices, limited spatiotemporal resolution, and undesired
inter-channel crosstalk in implantable systems. Addressing these challenges may require innovative approaches in
electrolyte engineering. This perspective summarizes the latest advancements and ongoing hurdles in the
electrolyte engineering of organic electrochemical transistors, highlighting their potential to revolutionize advanced
electrophysiological applications.

Keywords: Organic electrochemical transistors, electrolyte engineering, electrophysiology

INTRODUCTION
Electrophysiology, depending on its application scenarios, unveils the electrical properties inherent in heart
tissues and living neurons . This empowers scientists to underpin diverse heart rhythm abnormalities
[5,6]
[3,4]
[1,2]

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