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Marcet et al. The inflamed CNS takes hits centrally and peripherally

sympathetic and parasympathetic tone affect the Health, National Institute of Neurological Disorders
splenic response to CNS injury, and targeting this and Stroke 1R01NS071956, 1R01NS090962,
response has the potential for novel therapeutic 1R21NS089851, 1R21NS094087 and 1R21NS094908,
strategies. Department of Defense W81XWH-11-1-0634,
James and Esther King Foundation for Biomedical
A PARADIGM-SHIFT IN OUR Research Program, SanBio Inc., KM Pharmaceuticals,
UNDERSTANDING OF CNS INFLAMMATION NeuralStem Inc, and Karyopharm Inc. The content is
solely the responsibility of the authors and does not
Many neurological disorders, including traditionally necessarily represent the official views of the sponsors.
considered acute injuries such as stroke and TBI,
have now been recognized as being plagued by Conflicts of interest
neuroinflammation, which significantly contributes C.V. Borlongan has patents and patent applications
to the disease progression and is associated relating to stem cell therapy for stroke and TBI.
with secondary cell death reminiscent of chronic
neurodegeneration. A worsening prognosis of stroke Patient consent
and TBI has implicated massive inflammation, arising There is no patient data involved.
not just from the injured but equally robustly detected Ethics approval
from the peripheral organs, specifically the spleen.
By investigating the sources and mechanisms of Not applicable.
neuroinflammation, in particular the role of spleen-
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C.V. Borlongan is supported by National Institutes of in experimental and human stroke. J Cereb Blood Flow Metab
90 Neuroimmunology and Neuroinflammation ¦ Volume 4 ¦ May 17, 2017