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Rice et al. Minocycline in spinal cord injury

MMP-2 MMP-3 MMP-7 MMP-8

MMP-9 MMP-10 MMP-11 MMP-12

MMP-13 MMP-14 MMP-15 MMP-16

MMP-17 MMP-19 MMP-20 MMP-21

MMP-23 MMP-24 MMP-25 MMP-28

V M V M V M V M V M V M V M V M V M V M V M V M
Naive 1d 2d 5d Naive 1d 2d 5d Naive 1d 2d 5d Naive 1d 2d 5d
Figure 1: No impact of minocycline treatment on the profile of MMPs after SCI. While the expression of several MMPs was altered after
SCI, none of these MMPs were significantly different between the vehicle and minocycline groups. Values are mean ± SEM of 4 samples
from vehicle (V) or minocycline (M) group, at 1, 2 or 5 days after injury. *P < 0.05, **P < 0.01 and ***P < 0.001 compared to naïve controls.
All analyses were by one-way ANOVA with Tukey’s multiple comparisons. MMPs: matrix metalloproteinases; SCI: spinal cord injury

246 Neuroimmunology and Neuroinflammation ¦ Volume 4 ¦ November 28, 2017