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Liu et al. Neuroimmunol Neuroinflammation 2017;4:158-66 Neuroimmunology and
DOI: 10.20517/2347-8659.2017.09
Neuroinflammation

www.nnjournal.net
Topic: Stroke Open Access

Role of neuroinflammation in ischemic stroke

Rui Liu , Meng-Xian Pan , Jun-Chun Tang , Ya Zhang , Hua-Bao Liao , Yang Zhuang , Dan Zhao , Qi Wan 1,2
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1 Department of Physiology, Collaborative Innovation Center for Brain Science, School of Basic Medical Sciences, School of Medicine, Wuhan
University, Wuhan 430071, Hubei, China.
2 Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, Shandong, China.
Correspondence to: Dr. Qi Wan, Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 308 Ningxia Street, Qingdao 266071,
Shandong, China. E-mail: qwanwh@hotmail.com
How to cite this article: Liu R, Pan MX, Tang JC, Zhang Y, Liao HB, Zhuang Y, Zhao D, Wan Q. Role of neuroinflammation in ischemic stroke.
Neuroimmunol Neuroinflammation 2017;4:158-66.
Dr. Qi Wan is a Professor in the Institute of Neuroregeneration and Neurorehabilitation at Qingdao University. He is
also a Vice Dean for Research in the medical school. Before he joined to Qingdao University, he was a Professor at
Wuhan University (2013-2017) and a tenured Associate Professor at University of Nevada at Reno (2008-2012) and
a Senior Scientist in the Toronto Western Research Institute (2000-2008). His research is focused on understanding
the cellular and molecular mechanisms underlying the roles of neurotransmitter receptors in synaptic plasticity and
cerebral ischemic/reperfusion injury, and the role of endogenous neurogenesis in brain repair.

ABSTRACT
Article history: Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation
Received: 14-02-2017 in the brain that results from thrombotic blockage. Neuroinflammation occurs initially
Accepted: 20-07-2017 depending on activated resident microglia that has the same function as the macrophage.
Published: 28-08-2017 Activated microglia participates in the neuroinflammatory process by phagocytosing the
injured brain cells and producing the pro- and anti-inflammatory mediators. In this review,
Key words: the authors present an overview of the role of microglia in mediating neuroinflammation in
Microglia, ischemic stroke.
ischemic stroke,
neuroinflammation

INTRODUCTION common at approximately 85%) causing cerebral,
retinal, and spinal infarction and hemorrhagic stroke
Stroke is an acute episode of focal dysfunction of the (15%) that may result from intracerebral hemorrhage
brain, retina or spinal cord lasting longer than 24 h, or and subarachnoid hemorrhage [Figure 1]. Almost
for any duration if imaging (computed tomography or 90% of strokes are attributable to risk factors such
magnetic resonance imaging) or autopsy show focal as hypertension, regular physical inactivity, high
infarction or hemorrhage relevant to the symptoms. apolipoprotein, insufficient diet quality, psychosocial
Stroke is comprised of ischemic stroke (most factors, current smoking, cardiac causes, high alcohol

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