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Chen et al.                                                                                                                                                        Characteristics of viral encephalitis with epilepsy

           disturbance  in the acute phase  is severer  than for   4.   Shen YQ. Application value analysis of EEG in the diagnosis of viral
           other patients.  Therefore, this study suggests taking   encephalitis. Chin Mod Med 2015;5:96-7, 100.
                        [21]
           active antiepileptic treatment for patients with frequent   5.   Peng J, Luo TY, Lu FJ, Ouyang Y, Fang WD, Wu JQ. MRI, DWI
                                                                 and 1H-MRS features of viral encephalitis: report of 36 cases. Acta
           seizures.  As we lack follow-up investigation  of viral   Academiae Medicinae Militaris Tertiae 2009;3:257-60.
           encephalitis patients after discharge, we are unable to   6.   Qiao XH, Tong MQ, Yang F, Wang J, Ding CY. Research status of viral
           determine which AEDs have definite advantage over     encephalitis complicated with epilepsy. Chin J Clinicians (Electronic
           the others. The subject of viral encephalitis complicated   Edition) 2012;11:3025-8. (in Chinese)
           with epilepsy remains for further study.           7.   Misra UK, Kalita J. Seizures in encephalitis: predictors and outcome.
                                                                 Seizure 2009;18:583-7.
           Authors’ contributions                             8.   Singh TD, Fugate JE, Hocker SE, Rabinstein AA. Postencephalitic
                                                                 epilepsy:  clinical  characteristics  and  predictors.  Epilepsia
           Concept: S.Y. Chen, W. Ma, Y.Y. Chen, X.W. Fan        2015;56:133-8.
           Design: S.Y. Chen, X.W. Fan                        9.   Huang  D,  Huang  YL,  Liu  T.  Clinical  characteristics  of  viral
           Literature search: S.Y. Chen, W. Ma, Y.Y. Chen        encephalitis  patients  with secondary  epilepsy.  Chin Tropical  Med
           Data analysis: S.Y. Chen                              2014;4:486-7, 495.
           Manuscript preparation: S.Y. Chen, X.W. Fan        10.  Gong SH, Cao ZH, Song JH. On examination of cerebrospinal fluid of
                                                                 viral encephalitis patients. J Brain Nerv Dis 2008;6:694-6.
           Manuscript editing: S.Y. Chen, X.W. Fan            11.  Feng YK. Clinical Electroencephalography. Beijing: People’s Medical
           Manuscript review: S.Y. Chen, X.W. Fan                Publishing House; 1980. p. 62-4.
                                                              12.  Whitley  RJ,  Gnann  JW.  Viral  encephalitis:  familiar  infections  and
           Financial support and sponsorship                     emerging pathogens. Lancet 2002;359:507-13.
           None.                                              13.  Kuramoto T, Daikoku T, Yoshida Y, Takemoto M, Oshima K, Eizuru Y,
                                                                 Kanda Y, Miyawaki T, Shiraki K. Novel anticytomegalovirus activity
           Conflicts of interest                                 of immunosuppressant mizorihine and its synergism with ganciclovir.
           There are no conflicts of interest.                   J Pharmacol Exp Ther 2010;333:816-21.
                                                              14.  Dong YP. Clinical observation of methylpredinsolone combined with
           Patient consent                                       immunoglobulin  in  the  treatment  of severe  viral  encephalitis.  Clin
                                                                 Med 2014;5:20-1.
           Patient consent was obtained for publishing this work.  15.  Zhen HJ, Qiu YQ, Zhu PQ. Clinical analysis of 431 cases of central
                                                                 nervous system infection. Chin J Infectious Dis 2006;3:190-1.
           Ethics approval                                    16.  Usha KM, Chong  T, Jayantee  K.  Viral  encephalitis  and  epilepsy.
           Ethics committee approval was obtained for publishing   Epilepsia 2008;49:S13.
           this work.                                         17.  Shao DB,Sun HC. Clinical progress of viral encephalitis. Chin Gen
                                                                 Pract 2008;20:1817-9.
                                                              18.  Ai  TM.  Analysis  of  prognostic  factors  in  67  patients  with  viral
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