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severity, quality of sleep, and treatment adherence schizophrenia: two-year outcome of intermittent and maintenance
medication strategies. Schizophr Res 2002;53:145-59.
were found in patients with depression. However, 13. Kamali M, Kelly BD, Clarke M, Browne S, Gervin M, Kinsella
more research is needed to identify possible risk A, Lane A, Larkin C, O’Callaghan E. A prospective evaluation
factors that can be related to treatment non-adherence of adherence to medication in first episode schizophrenia. Eur
Psychiatry 2006;21:29-33.
to, in a second step, determine strategies to improve 14. Linden M, Godemann F, Gaebel W, Köpke W, Müller P, Müller-
treatment adherence. Treatment non-adherence might Spahn F, Pietzcker A, Tegeler J. A prospective study of factors
be reduced, and at best prevented, if specific predictors influencing adherence to a continuous neuroleptic treatment
program in schizophrenia patients during 2 years. Schizophr Bull
can be related to the adherence behavior of psychiatric 2001;27:585-96.
patients. Furthermore, identifying the characteristics 15. Last CG, Thase ME, Hersen M, Bellack AS, Himmelhoch
of clinical patients who drop out of treatment could JM. Patterns of attrition for psychosocial and pharmacologic
treatments of depression. J Clin Psychiatry 1985;46:361-6.
lead to improvements in the care these patients receive. 16. Tedlow JR, Fava M, Uebelacker LA, Alpert JE, Nierenberg AA,
Rosenbaum JF. Are study dropouts different from completers?
Acknowledgments Biol Psychiatry 1996;40:668-70.
We thank Dr. Marie Brill; she is the director of the 17. Leserman J. HIV disease progression: Depression, stress, and
possible mechanisms. Biol Psychiatry 2003;54:295-306.
LVR-Klinik Bedburg-Hau and made this study possible. 18. De Crescenzo F, Perelli F, Armando M, Vicari S. Selective
Moreover, we thank Prof. Gilles van Luijtelaar and Prof. serotonin reuptake inhibitors (SSRIS) for post-partum depression
(PPD): a systematic review of randomized clinical trials. J Affect
Anton Coenen for their helpful comments. Disord 2014;152-154:39-44.
19. Gaebel W, Möller HJ, Buchkremer G, Ohmann C, Riesbeck
Financial support and sponsorship M, Wölwer W, Von Wilmsdorff M, Bottlender R, Klingberg S.
Pharmacological long-term treatment strategies in first episode
Nil. schizophrenia: study design and preliminary results of an ongoing
RCT within the German Research Network on Schizophrenia.
Conflicts of interest Eur Arch Psychiatry Clin Neurosci 2004;254:129-40.
There are no conflicts of interest. 20. Tsang HW, Fung KM, Chung RC. Self-stigma and stages of
change as predictors of treatment adherence of individuals with
schizophrenia. Psychiatry Res 2010;180:10-5.
REFERENCES 21. Yang J, Ko YH, Paik JW, Lee MS, Han C, Joe SH, Jung IK, Jung
HG, Kim SH. Symptom severity and attitudes toward medication:
1. Pinto-Meza A, Fernández A, Bruffaerts R, Alonso J, Kovess V, impacts on adherence in outpatients with schizophrenia.
Schizophr Res 2012;134:226-31.
De Graaf R, de Girolamo G, Matschinger H, Haro JM. Dropping 22. Afonso P, Brissos S, Cañas F, Bobes J, Bernardo-Fernandez
out of mental health treatment among patients with depression I. Treatment adherence and quality of sleep in schizophrenia
and anxiety by type of provider: results of the European Study of outpatients. Int J Psychiatry Clin Pract 2014;18:70-6.
the Epidemiology of Mental Disorders. Soc Psychiatry Psychiatr 23. Phillips KD, Moneyham L, Murdaugh C, Boyd MR, Tavakoli A,
Epidemiol 2011;46:273-80.
2. Ong JC, Kuo TF, Manber R. Who is at risk for dropout from Jackson K, Vyavaharkar M. Sleep disturbance and depression as
barriers to adherence. Clin Nurs Res 2005;14:273-93.
group cognitive-behavior therapy for insomnia? J Psychosom 24. Cohrs S. Sleep disturbances in patients with schizophrenia:
Res 2008;64:419-25.
impact and effect of antipsychotics. CNS Drugs 2008;22:939-62.
3. Herman S, Blumenthal JA, Babyak M, Khatri P, Craighead WE, 25. Szklo-Coxe M, Young T, Finn L, Mignot E. Depression:
Krishnan KR, Doraiswamy PM. Exercise therapy for depression relationships to sleep paralysis and other sleep disturbances in a
in middle-aged and older adults: predictors of early dropout and community sample. J Sleep Res 2007;16:297-312.
treatment failure. Health Psychol 2002;21:553-63. 26. Glynn SM. Psychiatric rehabilitation in schizophrenia: advances
4. Haynes RB. Determinants of compliance: the disease and the and challenges. Clin Neurosci Res 2003;3:23-33.
mechanics of treatment. In: Haynes RB, Taylor DW, Sacket DL, 27. World Health Organization. The ICD-10 Classification of Mental
editors. Compliance in health care. Baltimore: Johns Hopkins and Behavioural Disorders: Clinical Descriptions and Diagnostic
University Press; 1979. p. 49-62. Guidelines. Geneva, CH: World Health Organization Press; 1992.
5. Miller R, Ream G, McCormack J, Gunduz-Bruce H, Sevy 28. American Psychiatric Association. Diagnostic and Statistical
S, Robinson D. A prospective study of cannabis use as a risk Manual of Mental Disorders. 5th ed. Arlington, VA: American
factor for non-adherence and treatment dropout in first-episode Psychiatric Publishing; 2013.
schizophrenia. Schizophr Res 2009;113:138-44. 29. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression
6. Helbig S, Fehm L. Problems with homework in CBT: rare exception Inventory-II. San Antonio, TX: Psychological Corporation; 1996.
or rather frequent? Behav Cogn Psychoth 2004;32:291-301. 30. Kay SR, Fiszbein A, Opler LA. The Positive and Negative
7. Kazantzis N. Power to detect homework effects in psychotherapy Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull
outcome research. J Consult Clin Psychol 2000;68:166-70. 1987;13:261-76.
8. Startup M, Wilding N, Startup S. Patient treatment adherence 31. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The
in cognitive behaviour therapy for acute psychosis: the role of Pittsburgh sleep quality index: a new instrument for psychiatric
recovery style and working alliance. Behav Cogn Psychoth practice and research. Psychiatry Res 1989;28:193-213.
2006;34:191-9. 32. Kyle SD, Morgan K, Spiegelhalder K, Espie CA. No pain, no
9. McCann TV, Boardman G, Clark E, Lu S. Risk profiles for non- gain: an exploratory within-subjects mixed-methods evaluation
adherence to antipsychotic medications. J Psychiatr Ment Health of the patient experience of sleep restriction therapy (SRT) for
Nurs 2008;15:622-9. insomnia. Sleep Med 2011;12:735-47.
10. Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV. 33. Fischer J, Mayer G, Peter JH, Riemann D, Sitter H, editors.
Prevalence of and risk factors for medication nonadherence in Nicht-erholsamer Schlaf. Non-relaxing sleep. Guideline, “S2” of
patients with schizophrenia: a comprehensive review of recent the German Society of Sleep Research and Sleep Medicine. [In
literature. J Clin Psychiatry 2002;63:892-909. German] Berlin: Wissenschafts-Verlag; 2002.
11. Nosé M, Barbui C, Tansella M. How often do patients with 34. IBM Corp. IBM SPSS Statistics for Windows, Version 22.0.
psychosis fail to adhere to treatment programmes? A systematic Armonk, NY: IBM Corp; 2013.
review. Psychol Med 2003;33:1149-60. 35. McLachan GJ, editor. Discriminant analysis and statistical
12. Gaebel W, Jänner M, Frommann N, Pietzcker A, Köpcke W, Linden pattern recognition. New York, NY: Wiley; 1992.
M, Müller P, Müller-Spahn F, Tegeler J. First vs. multiple episode 36. Sax PE, Meyers JL, Mugavero M, Davis KL. Adherence to

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