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Original Article

Symptom severity, quality of sleep, and

treatment adherence among patients suffering

from schizophrenia and depression

Peggy Bosch 1,2,3 , Janina Waberg , Maurits van den Noort , Heike Staudte , Sabina Lim , Jos Egger 1,5,6,7
2
3
1,2
3,4
1 Centre for Cognition, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 GL Nijmegen, the
Netherlands.
2 Psychiatric Research Institute, LVR-Klinik Bedburg-Hau, 47511 Bedburg-Hau, Germany.
3 Research Group of Pain and Neuroscience, Kyung Hee University, Seoul 130-701, South Korea.
4 Brussels Institute for Applied Linguistics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
5 Behavioural Science Institute, Radboud University Nijmegen, 6500 GL Nijmegen, the Netherlands.
6 Centre of Excellence for Neuropsychiatry, Vincent van Gogh Institute for Psychiatry, 5803 AC Venray, the Netherlands.
7 Pompe Institute for Forensic Psychiatry, PRO Persona, 6503 CK Nijmegen, the Netherlands.

Dr. Peggy Bosch received her PhD from the Radboud University, Nijmegen in the
Netherlands and works as a clinical psychologist for the LVR-Klinik Bedburg-Hau in
Germany. She is especially interested in schizophrenia, depression and sleep disorders.

A B S T R AC T
Aim: Treatment non-adherence is a common problem in patients suffering from schizophrenia and depression. This study investigated
the possible relationships between symptom severity, quality of sleep, and treatment adherence. Methods: Thirty outpatients with
schizophrenia and 58 outpatients with depression were enrolled in this study. The beck depression Inventory-II, the positive and negative
syndrome scale, and the pittsburgh sleep quality index were used to assess symptom severity and quality of sleep, and sleep log data were
used to measure treatment adherence. Results: The preliminary results showed no significant relationship between symptom severity
and treatment adherence or between quality of sleep and treatment adherence in patients with depression. However, a significant positive
relationship was found between negative symptoms and treatment adherence and a significant negative relationship between quality of
sleep and treatment adherence in patients with schizophrenia. Conclusion: The present exploratory study revealed a positive relationship
between symptom severity and treatment adherence and a negative relationship between quality of sleep and treatment adherence in
patients with schizophrenia, but no significant relationships in patients with depression were found. Future studies are needed in order to
gain a better understanding of possible risk factors related to treatment non-adherence.
Key words: Depression; quality of sleep; schizophrenia; symptom severity; treatment adherence

INTRODUCTION known about possible risk factors that might predict
patient dropout. Findings by Herman et al. indicate
[2]
[3]
Dropout is a serious problem in treating patients that early treatment dropout is an essential factor in
because treatment can only be effective if delivered determining treatment success and failure because
[1]
adequately and completely. To date, very little is in case of dropout, patients receive little or nothing
of the intervention involved and, therefore, cannot
Corresponding Author: Dr. Peggy Bosch, Centre for Cognition,
Donders Institute for Brain, Cognition and Behaviour, Radboud
University Nijmegen, Postbus 9104, Montessorilaan 3, 6500 GL This is an open access article distributed under the terms of the Creative
Nijmegen, the Netherlands. E-mail: P.bosch@donders.ru.nl Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows
others to remix, tweak, and build upon the work non-commercially, as long as the
author is credited and the new creations are licensed under the identical terms.
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Website:
www.nnjournal.net How to cite this article: Bosch P, Waberg J, van den Noort M, Staudte
H, Lim S, Egger J. Symptom severity, quality of sleep, and treatment
adherence among patients suffering from schizophrenia and depression.
Neuroimmunol Neuroinflammation 2016;3:109-16.
DOI: 10.20517/2347-8659.2015.54
Received: 11-12-2015; Accepted: 16-03-2016

© 2016 Neuroimmunology and Neuroinflammation | Published by OAE Publishing Inc. 109