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Page 330                                Genvigir et al. J Transl Genet Genom 2020;4:320-55  I  http://dx.doi.org/10.20517/jtgg.2020.37

              Ref.   [50]  [22]  [49]   [38]     [41]       [53]         [48]     [36]    [54]     [43]



              Clinical outcomes  No association of UGT1A9  c.-275T>A variant with AR  No association of UGT1A9   c.-275T>A and c.98T>C   variants with neutrophil   UGT1A9 rs6744284CC  genotype was associated  with higher gastrointestinal   symptom rating scale   (GSRS) score for   constipation at week 1  No association of  UGT2B7c.-840G>A variant  with diarrhea or leukopenia  No association of UGT2B7   c.-900A>G variant with   adverse events (diarrhea   and leukopenia)







                 --                  counts  -              -            -        -
              Pharmacokinetics  No association of   UGT1A9 -118delT   variant with MPA   pharmacokinetics  -  No association of   UGT1A9 c.-275T>A and   c.98T>C variants with   MPA exposure (AUC)  No association of   UGT1A9 c.-440C>T, c.-  331T>C and I399 T>C   variants with MPA C/D   (days 3-8)  -  UGT2B7 c.-842AA  (802CC) genotype was   associated with higher   AcMPAG AUC 0-9    at Month 1 and 3, on  sirolimus treatment (n =   40)  UGT2B7 802TT   genotype individuals  s








             Immunosuppressive   regimen  MMF  Cyclosporine  Tacrolimus  Corticosteroids  MMF  Cyclosporine Tacrolimus  Sirolimus  Corticosteroids  MMF  Tacrolimus  Corticosteroid-free  One-year follow-up  MMF  Cyclosporine  Tacrolimus  Corticosteroids   40-day follow-up  MMF  EC-MPS  Cyclosporine  Tacrolimus  Corticosteroids   Six-month follow-up  MMF  Cyclosporine  Tacrolimus  Sirolimus  Corticosteroids Three-  month follow-up  MMF  Cyclosporine  Corticosteroid-free   A











              Population   118 adult patients   (China)  145 adult patients   (Brazil)  21 adult patients   (Canada)  408 adult patients   (China)  109 adult patients   (USA)  92 adult patients   (France)  40 adult patients  (Italy)  72 adult patients (Japan)  332 adult patients   38 pediatric patients   (USA)









              Study design  Retrospective  Retrospective (Case-  control)  Prospective  Retrospective  Prospective  Prospective, multicenter  Mixed  Prospective  Prospective  (FDCC  Study)  Retrospective (Case-  control)







              Allele frequency  c.-275A: 14%  c.-440T: 3%  c.-331C: 3%  c.I399C: 47%  rs6744284T: 32%  c.-842G: 55%  UGT2B7*2(T): 33%  c.-840G: 50%  c.-900G:45%






                 -      -         c.98C: 0%                   802T: 55%  802T: 41%


              Variant                                                                  (802C>T, UGT2B7*2)
                                                 rs6744284   rs7438135  (c.-840G>A,   c.-842G>A or c.-  900G>A)  rs7662029  (c.-327G>A)  rs73823859  (-79G>A)  rs12233719  (c.211G>T)  rs7439366  rs62298861  (IVS1+985A>G)





              Gene                                          UGT2B7
   40   41   42   43   44   45   46   47   48   49   50