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Genvigir et al. J Transl Genet Genom 2020;4:320-55 I http://dx.doi.org/10.20517/jtgg.2020.37 Page 335
Ref. [30] [64] [27] [22] [24] [49] [38] [37] [30] [27]
Clinical outcomes No association of ABCC2 c.-24C>T and c.3972C>T variants with AR, DGF, graft function or adverse events - No association of ABCC2 c.-24C>T and rs12762549 variants with leukopenia No association of ABCC2 c.-24C>T and c.1249G>A variants with AR No association of ABCC2 c.1249G>A and c.3972C>T variants with DGF or AR No association of ABCC2 No association of ABCC2 c.-24C>T and c.1249G>A c.-24C>T and c.1249G>A variants wit
Pharmacokinetics Donors’ ABCC2 c.1249A allele was associated with a reduced peak and early (AUC 0-2 ) exposure No association of ABCC2 c.1249G>A and c.3972C>T variants with variants with MPA exposure (AUC) ABCC2 c.-24TT genotype was possibly associated with higher MPA C/D (days 3-8) No association of ABCG2 c.421C>A variant with MPA or MPAG exposure (AUC 4-12 or AUC 0-12 )
- to MPA - - MPA C/D - -
Immunosuppressive regimen EC-MPS Tacrolimus Corticosteroids Three-month follow-up MMF EC-MPS Cyclosporine Tacrolimus Corticosteroids MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids One-year follow-up MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids EC-MPS Tacrolimus Corticosteroids One-year follow-up MMF Tacrolimus Corticosteroid-free One-year follow-up MMF Cyclosporine Tacrolimus Corticosteroids 40-day follow-up
Population 148 adult patients (Brazil) 68 adult patients (Croatia) 284 pediatric and young adult patients (USA) 145 adult patients (Brazil) 97 adult patients (Brazil) 21 adult patients (Canada) 408 adult patients (China) 37 adult patients (China) 148 adult patients (Brazil) 284 pediatric and young adult patients (USA)
Study design Prospective, multicenter Prospective Retrospective (Case- Control), multicenter Retrospective (Case- control) Prospective Prospective Retrospective Prospective, Multicenter (Case-control) Prospective, multicenter Retrospective (Case- Control), multicenter
Allele frequency c.-24T: 14% c.3972T: 32% c.-24T: 17% c.1249A: 24% - c.-24T: 20% c.1249A: 22% c.1249A: 19% c.3972T: 30% c.-24T: 19% c.1249A: 0% c.-24T: 21% c.1249A: 8% c.421A: 26% c.421A: 8% -
Variant
rs2231142 (c.421C>A) rs4491984G>A
Gene ABCG2