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Page 332 Genvigir et al. J Transl Genet Genom 2020;4:320-55 I http://dx.doi.org/10.20517/jtgg.2020.37
Ref. [49] [38] [30] Ref. [23] [25] [26] [13]
Clinical outcomes No association of UGT2B7 c.211G>T and 802C>T variants with neutrophil count - No association of UGT2B7 c.372A>G variant with AR, DGF, graft function or adverse events Clinical outcomes ABCB1 c.3435T allele was associated with higher requirement of MMF dose reduction due to diarrhea. No association of ABCB1 c.3435C>T variant with AR ABCB1 c.2677T allele and c.3435T/c.2677T/ c.1236T haplotype was associated with
Pharmacokinetics No association of UGT2B7 c.211G>T and 802C>T variants with MPA exposure (AUC) UGT2B7 rs7662029 GG genotype was possibly associated with higher MPA C/D (days 3-8) - Pharmacokinetics No association of ABCB1 c.3435C>T variant with daytime and nighttime MPA AUC 0-12 - - -
Immunosuppressive regimen MMF Tacrolimus Corticosteroid-free One-year follow-up MMF Cyclosporine Tacrolimus Corticosteroids 40-day follow-up EC-MPS Tacrolimus Corticosteroids Three-month follow-up Immunosuppressive regimen MMF Tacrolimus Corticosteroids Six-week follow-up MMF Cyclosporine Corticosteroids One-year follow-up MMF or Azathioprine Cyclosporine Tacrolimus Corticosteroids MMF Cyclosporine Tacrolimus mTOR inhibito
Population 21 adult patients (Canada) 408 adult patients (China) 148 adult patients (Brazil) AcMPAG: acyl-MPA-glucuronide; AR: allograft rejection; AUC: area under the concentration-time curve; C/D: trough dose-adjusted concentration; DGF: delayed graft function; EC-MPS: enteric- Population 30 adult patients (Japan) 237 adult patients 207 pediatric patients (Poland) (France)
Study design Prospective Retrospective Prospective, multicenter coated mycophenolate sodium salt; eGFR: estimated glomerular filtration rate; MMF: mycophenolate mofetil; MPA: mycophenolic acid; MPAG: MPA-7-O-glucuronide Study design Prospective Prospective, multicenter (CAESAR study) Retrospective Retrospective (Transgene 218 adult patients study)
Allele frequency c.211T: 5% 802T: 10% c.211T: 12% c.-327A: 30% c.372G: 14% Table 2. Genes related to mycophenolic acid transport in kidney transplantation Allele frequency c.3435T: 42% c. 1236T: 40% c. 2677G: 58% c.3435T: 49% 417G: 13% 61G: 9% c.3435T: 55% c.3435T: 41%
Variant Variant rs9282564 (61A>G)
rs28365063 (c.372A>G) rs3842 (417A>G) rs1128503 (c. 1236C>T) rs2032582 (c.2677G>T/A) rs1045642 (c.3435C>T)
Gene Gene ABCB1
