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Genvigir et al. J Transl Genet Genom 2020;4:320-55 I http://dx.doi.org/10.20517/jtgg.2020.37 Page 333
Ref. [59] [27] [24] [62] [48] [65] [25] [45] [39]
Clinical outcomes No association of ABCB1 A and c.3435C>T variants with diarrhea or leukopenia No association of ABCB1 c.1236C>T, c.2677G>T/A and c.3435C>T variants with leukopenia No association of ABCB1 c.1236C>T and with DGF or AR ABCC2 c.-24T allele was associated with diarrhea. No association of ABCC2 c.-24C>T variant with AR or hematological disorders No association of ABCC2 No association of ABCC2 c.-24C>T variant with
Pharmacokinetics No association of ABCB1 c.1236C>T, c.2677G>T/A c.1236C>T, c.2677G>T/ and c.3435C>T variants with exposure to MPA, MPAG or AcMPAG - No association of ABCB1 c.1236C>T and c 2677G>T/A variants with c.2677G>T/A variants MPA C/D ABCC2 c.-24C>T and c.3972C>T variants were associated with protection from a reduction in MPA exposure (AUC 0-12 ) in patients with liver dysfunction, at day 7. In stable kidney recipients,
Immunosuppressive regimen MMF Cyclosporine Tacrolimus Corticosteroids One-year follow-up MMF Cyclosporine Tacrolimus Sirolimus Corticosteroids One-year follow-up EC-MPS Tacrolimus Corticosteroids One-year follow-up MMF Tacrolimus Corticosteroids One-year follow-up MMF Cyclosporine Corticosteroid-free At Month 6 MMF Tacrolimus Corticosteroids At day 28 MMF Cyclosporine Corticosteroids One-year follow-up MMF Tacrolimus Cort
Population 338 adult patients 284 pediatric and young adult patients (USA) 97 adult patients (Brazil) 95 adult patients (Belgium) 40 adult patients (Italy) 87 adult patients (Japan) 237 adult patients 100 adult patients (Belgium) 338 adult patients
Study design Prospective (FDCC Study) Retrospective (Case- Control), multicenter Prospective Prospective Mixed Prospective Prospective, multicenter (CAESAR study) Prospective Prospective, multicenter (FDCC Study)
Allele frequency c.1236T: 41% c.3435T: 50% - c.1236T: 36% c. 2677T/A: 32/4% -1549A: 38% -1023A: 13% -1019G: 43% c.-24T: 23% c.1249A: 17% c.3972T: 32% c.4544A: 9% c.-24T: 20% c.1249A: 28% c.-24T: 26% c.3972T: 36% rs2804402G: 42% rs17222723A: 7% - c.-24T: 18% c.3972T: 34%
Variant rs2273697 (c.1249G>A) rs17222723 (3600T>A) rs3740066 (c.3972C>T)
rs1885301 (-1549G>A) rs7910642 (-1023G>A) rs2804402 (-1019A>G) rs717620 (c.-24C>T) rs113646094 (1446C>G) rs8187694 (3563T>A) rs8187710 (c.4544G>A) rs12762549 rs2804402
Gene ABCC2
