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Yang et al. PANDA, LincRNA-p21, PUMA in Xuanwei

from Xuanwei and 42 patients with lung cancer were lung tissues (P > 0.05). There was no significant
from non-Xuanwei regions. All patients were ethnic difference in the expression of PANDA in lung cancer
Han Chinese. Non-Xuanwei regions included Kunming, tissue and normal lung tissue between the 2 groups
Yuxi, Baoshan, Dali, Chuxiong, Honghe, and other (P > 0.05). Expression of PUMA in lung cancer tissue
areas. Eighteen cases of squamous cell carcinoma was lower than normal tissue (P < 0.05). Expression
and 27 cases of adenocarcinoma were from Xuanwei. of PUMA in patients from Xuanwei was lower than that
Seventeen cases of squamous cell carcinoma and 25 of non-Xuanwei patients, not only in cancer tissue, but
cases of adenocarcinoma were from non-Xuanwei. also in normal lung (P < 0.05) [Tables 3 and 4].
There were 24 males and 21 females from Xuanwei
and 24 males and 18 females from non-Xuanwei Expression of LincRNA-p21, PANDA, and
regions. Meanage of patients from Xuanwei was 54.91 PUMA in squamous cell carcinoma and
± 9.62 years while in the non-Xuanwei group, the mean adenocarcinoma
age was 58.33 ± 10.13 years. There were 21 patients There was no significant difference in the expression
from Xuanwei and 22 from non-Xuanwei who were of three genes in squamous cell carcinoma and
smokers. Eighteen patients from Xuanwei consumed adenocarcinoma (P > 0.05) [Table 5].
alcohol whereas 16 from non-Xuanwei did [Table 2].
Expression of LincRNA-p21, PANDA, PUMA in
Expressions of LincRNA-p21, PANDA, and smokers and non-smokers
PUMA in Xuanwei and non-Xuanwei patients The expression of LincRNA-p21, PANDA, PUMA in
Expression of LincRNA-p21 in lung tissues of Xuanwei smokers and non-smokers was showed in Table 6.
patients was increased (P < 0.05). There was no
significant difference in expression of it between 2 Analysis of correlation in expression of
groups of patients in lung cancer tissues and normal LincRNA-p21, PANDA and PUMA in tissues of
lung cancer patients from Xuanwei and non-
Table 2: Comparison between the two groups Xuanwei areas
LincRNA-p21 and PANDA in lung cancer tissues and
Xuanwei Non-Xuanwei normal lung tissues were characterized by positive
n 45 42 correlation. PANDA with PUMA in lung cancer
Squamous cell carcinoma 18 17
Adenocarcinoma 27 25 and normal lung tissue showed no corresponding
Male 24 24 correlation [Table 7].
Non-smoking 3 2
Smoking* < 400 7 9
Smoking > 400 14 13 Expression of LincRNA-p21, PANDA and PUMA
Female 21 18 in lung cancer patients from non-Xuanwei areas:
Non-smoking 21 18 LincRNA-p21 was positively correlated with PUMA
Smoking < 400 0 0 in normal tissue, but not in lung cancer tissue.
Smoking > 400 0 0 LincRNA-p21 and PANDA in lung cancer and normal
Age 54.91 ± 9.62 58.33 ± 10.13
Alcohol 18 16 lung tissue all showed positive correlation. PANDA was
*Smoking index: the number of cigarettes smoked per day x positively correlated with PUMA in normal lung tissue
number of years of smoking, high-risk groups > 400 but not in lung cancers [Table 8].
Table 3: Expression of LincRNA-p21, PANDA, PUMA in males and females
Gene Male Female P
LincRNA-p21 Xuanwei 15.18 ± 1.44 15.19 ± 1.65 0.63
Non-Xuanwei 13.33 ± 1.85 13.01 ± 1.05 0.51
PANDA Xuanwei 14.36 ± 1.65 14.38 ± 2.79 0.88
Non-Xuanwei 14.14 ± 1.23 14.03 ± 1.67 0.85
PUMA Xuanwei 5.32 ± 1.85 5.23 ± 1.43 0.74
Non-Xuanwei 7.45 ± 2.18 7.34 ± 2.42 0.77
Expression of the 3 genes in lung tissues of both males and females showed no statistical difference (P ＞ 0.05)

Table 4: Expression of LincRNA-p21, PANDA, PUMA in Xuanwei and non-Xuanwei patients
Gene Xuanwei Non-Xuanwei P
LincRNA-p21 Cancer tissue 15.12 ± 1.27 12.21 ± 1.51 0.03
Normal tissue 15.07 ± 1.42 12.19 ± 1.62 0.04
PANDA Cancer tissue 14.36 ± 1.46 14.08 ± 1.27 0.52
Normal tissue 14.44 ± 1.55 14.11 ± 2.32 0.47
PUMA Cancer tissue 5.14 ± 1.37 7.38 ± 2.74 0.01
Normal tissue 6.19 ± 1.43* 8.82 ± 2.89** 0.01
*P = 0.04 (cancer tissue vs. normal tissue); **P = 0.03 (cancer tissue vs. normal tissue)
Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ March 27, 2017 67