Page 168 - Read Online
P. 168

Tian et al.                                                                                                                                                   EMT drives anti-estrogen resistance in breast cancer

           Institutes of Health to W.P.S. (CA129359, CA177069,   effect of COX-2 on TGF-b signaling during mammary tumorigenesis.
           and CA194518).                                        FASEB J 2010;24:1105-16.
                                                              18.  Wrana  JL, Attisano  L,  Carcamo  J,  Zentella A, Doody J, Laiho  M,
           Conflicts of interest                                 Wang XF, Massague J. TGFb signals through a heteromeric protein
                                                                 kinase receptor complex. Cell 1992;71:1003-14.
           There are no conflicts of interest.                19.  Hall JM, McDonnell DP. The estrogen receptor b-isoform (ERb) of the
                                                                 human estrogen receptor modulates ERa transcriptional activity and is
           Patient consent                                       a key regulator of the cellular response to estrogens and antiestrogens.
                                                                 Endocrinology 1999;140:5566-78.
           Not applicable.                                    20.  Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT. Zebrafish
                                                                 prickle,  a  modulator  of  noncanonical  Wnt/Fz  signaling,  regulates
           Ethics approval                                       gastrulation movements. Curr Biol 2003;13:680-5.
           The study was approved by Institutional Scientific and   21.  Schiemann  WP,  Pfeifer  WM,  Levi  E,  Kadin  ME,  Lodish  HF.  A
           Ethical Committees.                                   deletion in the gene for transforming growth factor b type I receptor
                                                                 abolishes  growth  regulation  by  transforming  growth  factor  b  in  a
                                                                 cutaneous T-cell lymphoma. Blood 1999;94:2854-61.
           REFERENCES                                         22.  Chaffer CL, San Juan BP, Lim E, Weinberg RA. EMT, cell plasticity
                                                                 and metastasis. Cancer Metastasis Rev 2016;35:645-54.
           1.   Massague J.  TGFb  signalling in context.  Nat Rev Mol Cell Biol   23.  Wendt MK, Tian M, Schiemann WP. Deconstructing the mechanisms
               2012;13:616-30.                                   and consequences of TGF-b-induced EMT during cancer progression.
           2.   Tian M, Neil JR, Schiemann WP. Transforming growth factor-b and   Cell Tissue Res 2012;347:85-101.
               the hallmarks of cancer. Cell Signal 2011;23:951-62.  24.  Morrison  CD,  Parvani  JG,  Schiemann  WP.  The  relevance  of  the
           3.   Tian M, Schiemann WP. The TGF-b paradox in human cancer:  an   TGF-b paradox to EMT-MET Programs. Cancer Lett 2013;341:30-40.
               update. Future Oncol 2009;5:259-71.            25.  Taylor MA,  Amin J, Kirschmann DA,  Schiemann  WP. Lysyl
           4.   Parvani  JG,  Taylor  MA, Schiemann  WP. Noncanonical  TGF-b   oxidase  contributes  to  mechanotransduction-mediated  regulation
               signaling  during  mammary  tumorigenesis.  J  Mammary Gland Biol   of  transforming  growth  factor-b  signaling  in  breast  cancer  cells.
               Neoplasia 2011;16:127-46.                         Neoplasia 2011;13:406-18.
           5.   Taylor  MA,  Parvani  JG,  Schiemann  WP.  The  pathophysiology  of   26.  Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah
               epithelial-mesenchymal  transition  induced  by  transforming  growth   RL, Taylor SS, Engler AJ, Yang J. Matrix stiffness drives epithelial-
               factor-b  in  normal  and  malignant  mammary  epithelial  cells.  J   mesenchymal transition and tumour metastasis through a TWIST1-
               Mammary Gland Biol Neoplasia 2010;15:169-90.      G3BP2 mechanotransduction pathway. Nat Cell Biol 2015;17:678-88.
           6.   Arendt LM, Kuperwasser C. Form and function: how estrogen and   27.  Gilbert PM, Weaver VM. Cellular adaptation to biomechanical stress
               progesterone regulate the mammary epithelial hierarchy. J Mammary   across length scales in tissue homeostasis and disease. Semin Cell Dev
               Gland Biol Neoplasia 2015;20:9-25.                Biol 2017;67:141-152.
           7.   Finlay-Schultz J, Sartorius CA. Steroid hormones, steroid receptors,   28.  Band  AM,  Laiho  M.  Crosstalk  of  TGF-b  and  estrogen  receptor
               and breast cancer  stem cells.  J Mammary Gland Biol Neoplasia   signaling in breast cancer.  J Mammary Gland Biol Neoplasia
               2015;20:39-50.                                    2011;16:109-15.
           8.   Ali S, Coombes RC. Estrogen receptor  a in human breast cancer:   29.  Song RX, Zhang Z, Santen RJ. Estrogen rapid action  via protein
               occurrence  and  significance.  J  Mammary Gland Biol  Neoplasia   complex formation involving ERa and Src. Trends Endocrinol Metab
               2000;5:271-81.                                    2005;16:347-53.
           9.   Ali S, Coombes RC. Endocrine-responsive breast cancer and strategies   30.  Xie L, Law BK, Chytil  AM, Brown KA,  Aakre ME, Moses HL.
               for combating resistance. Nat Rev Cancer 2002;2:101-12.  Activation of the Erk pathway is required for TGF-b1-induced EMT
           10.  Osborne CK, Fuqua SA. Mechanisms of tamoxifen resistance. Breast   in vitro. Neoplasia 2004;6:603-10.
               Cancer Res Treat 1994;32:49-55.                31.  Santen RJ, Fan P, Zhang Z, Bao  Y, Song RX,  Yue  W. Estrogen
           11.  Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ. The   signals  via  an  extra-nuclear  pathway  involving  IGF-1R  and  EGFR
               role of Shc and insulin-like growth factor 1 receptor in mediating the   in  tamoxifen-sensitive  and  -resistant  breast  cancer  cells.  Steroids
               translocation of estrogen receptor a to the plasma membrane. Proc   2009;74:586-94.
               Natl Acad Sci U S A 2004;101:2076-81.          32.  Fan P, Wang J, Santen RJ, Yue W. Long-term treatment with tamoxifen
           12.  Song RX, Chen Y, Zhang Z, Bao Y, Yue W, Wang JP, Fan P, Santen RJ.   facilitates translocation of estrogen receptor a out of the nucleus and
               Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer   enhances  its  interaction  with  EGFR in  MCF-7 breast  cancer  cells.
               cells. J Steroid Biochem Mol Biol 2010;118:219-30.  Cancer Res 2007;67:1352-60.
           13.  Song RX, Zhang Z, Chen Y, Bao Y, Santen RJ. Estrogen signaling   33.  Thomson S, Petti F, Sujka-Kwok I, Mercado P, Bean J, Monaghan
               via a linear pathway involving insulin-like growth factor I receptor,   M, Seymour  SL,  Argast  GM, Epstein  DM, Haley  JD.  A  systems
               matrix metalloproteinases, and epidermal growth factor receptor to   view of epithelial-mesenchymal transition signaling states. Clin Exp
               activate  mitogen-activated  protein  kinase in MCF-7 breast cancer   Metastasis 2011;28:137-55.
               cells. Endocrinology 2007;148:4091-101.        34.  Hiscox  S, Jiang  WG,  Obermeier  K,  Taylor  K, Morgan  L,  Burmi
           14.  Kumar R, Wang RA, Mazumdar A, Talukder AH, Mandal M, Yang   R,  Barrow  D,  Nicholson  RI.  Tamoxifen  resistance  in  MCF7  cells
               Z, Bagheri-Yarmand R, Sahin  A,  Hortobagyi G,  Adam L, Barnes   promotes EMT-like behaviour and involves modulation of b-catenin
               CJ, Vadlamudi RK. A naturally occurring MTA1 variant sequesters   phosphorylation. Int J Cancer 2006;118:290-301.
               oestrogen receptor-a in the cytoplasm. Nature 2002;418:654-7.  35.  Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L,
           15.  Parvani JG, Davuluri G, Wendt MK, Espinosa C, Tian M, Danielpour   Abbruzzese JL, Gallick GE, Logsdon CD, McConkey DJ, Choi W.
               D, Sossey-Alaoui K, Schiemann WP. Deptor enhances triple-negative   Epithelial to mesenchymal transition contributes to drug resistance in
               breast cancer  metastasis  and chemoresistance  through coupling  to   pancreatic cancer. Cancer Res 2009;69:5820-8.
               survivin expression. Neoplasia 2015;17:317-28.  36.  McConkey DJ, Choi W, Marquis L, Martin F, Williams MB, Shah
           16.  Tian M, Schiemann WP. Preclinical efficacy of cystatin C to target the   J, Svatek R, Das A, Adam L, Kamat A, Siefker-Radtke A, Dinney
               oncogenic activity of transforming growth factor b in breast cancer.   C.  Role  of  epithelial-to-mesenchymal  transition  (EMT)  in  drug
               Transl Oncol 2009;2:174-83.                       sensitivity and metastasis in bladder cancer. Cancer Metastasis Rev
           17.  Tian M, Schiemann WP. PGE2 receptor EP2 mediates the antagonistic   2009;28:335-44.
            160                                                                  Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ August 21, 2017
   163   164   165   166   167   168   169   170   171   172   173