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Pippione et al. Steroidogenic enzymes in prostate cancer

Figure 11: Structures of some 5a-reductase inhibitors

40 in the AKR1D1 active site, a surrogate of SRD5A2, The carboxylic group at position-3 provided selective
that its inhibitory mechanism was the same as that of inhibition ofSRD5A2, as all the compounds of this
finasteride [97] . series showed minimal inhibition against the type I
enzyme.4-azasteroid-2-oximes (structures 45-47) were
Aggarwal et al. [98] studied similar steroidal molecules reported to be active against the SRD5A enzymes
(structures 42-44) able to inhibit the type II enzyme present on rat ventral prostate extract (both type 1 and
in the same range of concentration as finasteride. the type 2 isozymes were present) [99] .

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