Page 75 - Read Online

Pippione et al. Steroidogenic enzymes in prostate cancer

Figure 10: Structures of some nonsteroidal 17b-HSD3 inhibitors

benzophenone-1 [80] , tributyltin chloride and triphenyltin inhibitors of HSD17B3 have been designed and
chloride [86] have been identified as HSD17B3 developed, but none of them has reached the
inhibitors, but their use is considered harmful to normal clinic. One reason for this might be the difficulty in
sexual development, since this enzyme plays an identifying an appropriate species to conduct the
essential role in that process. functional assays. Due to little sequence homology
between human and other species isoforms, very
In the last decade, several steroidal and non-steroidal potent inhibitors of the human enzyme show little
Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ December 12, 2017 343