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Page 16 of 33 Mao et al. Chem Synth 2023;3:26 https://dx.doi.org/10.20517/cs.2022.41

Figure 10. (A) and (B) General Design of T-MAN for Fluorescence/MR Bimodal Imaging and Targeted PTT of Tumors; and (C)
schematic representation for fluorescence/MR imaging-guided PTT in gastric tumors in vivo [126] ; (D)-(F) Illustration of fluorescence
imaging by monitoring; and (G) the fluorescence images of ultrasmall Cu Se nanoparticles [127] . (A)-(C): Copyright © American Chemical
2-x
Society 2019; (D)-(G): Copyright © The Royal Society of Chemistry 2019. NIR: near-infrared region; MR: magnetic resonance; MRI:
magnetic resonance imaging; PTT: photothermal therapy.

nodes in live mice. Shi et al. also reported on another novel fluorescent CuS nanoparticle (CuS-Cy5.5-RGD)
capable of noninvasive multimodal imaging and targeted PTT of gastric cancer cells with intra-lymph node
metastases. In addition, it allowed for rapid and noninvasive self-monitoring of PTT efficacy on metastatic
sentinel lymph nodes in living mice . In another paper, a NIR Cu particular responsive probe (named
[107]
2+
NCM) was synthesized by Han at el., as shown in Figure 10D. It loaded ultrasmall copper selenide
nanoparticles on the surface to monitor the systematical release of copper ions in cells and animals .
[127]
Figure 10E and 10F show the metabolic and tissue distribution of the material. Meanwhile, the unlocked
Cu can react particularly with non-fluorescent NCM to form NCM-1 with strong NIR fluorescence to
2+
realize the FLI at 735 nm, as shown in Figure 10G. It consisted of cuprous selenide as the main body and
was loaded with the non-fluorescent dye NCM. After the material was stimulated in vitro to release copper
ions and activate dyes, FLI can be achieved and used for both in vivo and in vitro fluorescence imaging.