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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 13 of 50
Figure 20. Biotransformation of sclareolide (84) with Cunninghamella elegans.
Figure 21. Biotransformation of (-)-guaiol (94) with Macrophomina phaseolina, Rhizopus
stolonifer, and Cunninghamella elegans.
[Figure 21], while Macrophomina phaseolina-catalyzed biotransformation of 94 resulted in two derivatives,
1(5)-guaien-11-ol-6-one (98) (2.1%), and 1-guaien-11-ol-3-one (99) (2%) [Figure 21].
[38]
BIOTRANSFORMATION OF DITERPENES
Biotransformation of sclareol (100)
Two new derivatives, 1β-hydroxysclareol (101) (1.3%) and 12-hydroxysclareol (102) (1%), were synthesized
through the biotransformation of the diterpene, sclareol (100) with Fusarium lini [Figure 22]. Similarly, two
new derivatives, 3β-hydroxysclareol (103) (2.7%) and 18-hydroxysclareol (104) (1.3%), and the two known
metabolites, 6α,18-dihydroxysclareol (105) (3.2%) and 11,18-dihydroxysclareol (106) (4.6%), were also
[39]
synthesized through the biotransformation of sclareol (100) with Rhizopus stolonifer [Figure 23].
