Page 70 - Read Online
P. 70
Page 16 of 50 Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02
Figure 26. Biotransformation of leucosceptrine (114) with Rhizopus stolonifer.
Figure 27. Biotransformation of oleanolic acid (117) with Fusarium lini.
[44]
afforded the metabolite, 3, 11-dioxoolean-12-en-30-oic acid (122) (2.5%) [Figure 28]. Compounds 120
(IC = 225.1 ± 0.5 μM), 121 (IC ≥ 300 μM), and 122 (IC = 144.2 ± 0.2 μM) exhibited good lipoxygenase
50
50
50
(LOX) inhibitory activity, as compared to the standard drug, baicalein (IC = 22.4 ± 0.5 μM). LOX inhibitors
50
are used for the treatment of various diseases, i.e., asthma, inflammation, cancer, and some autoimmune
diseases.
BIOTRANSFORMATION OF ANABOLIC-ANDROGENIC STEROIDS
Biotransformation of testosterone (123)
Biotransformation of the male steroidal hormone testosterone (123) with Curvularia lunata yielded 17-
dehydrotestosterone (124) (2.1%), while Pleurotus ostreatus-assisted transformation of 123 afforded 15α-
hydroxytestosterone (125) (2.9%) [Figure 29]. Four derivatives, testolactone (126) (4.6%) (anti-cancer
[45]
drug), 11α-hydoxytestolactone (127) (0.5%), 11α-hydroxyandrost-4-en-3, 17-dione (128) (0.3%), and 17β-
hydroxy-androst-4-en-3, 6-dione (129) (1%) were synthesized through the biotransformation of 123 with
Rhizopus stolonifer [Figure 29]. Similarly, biotransformation of 123 with Fusarium lini afforded four
[46]
