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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 15 of 50

Figure 24. Microbial transformation of andrographolide (107) with Cephalosporium aphidicola.

Figure 25. Microbial transformation of dehydroabietic acid (110) with Cunninghamella elegans Gibberella fujikuroi, and Cephalosporium
aphidicola.

hydroxyleucosceptrine (116) (2.6%) [Figure 26] .
[42]

BIOTRANSFORMATION OF TRITERPENE
Biotransformation of oleanolic acid (117)
Biotransformation of a pentacyclic triterpene, oleanolic acid (117) with Fusarium lini yielded a new
compound, 2α, 3β, 11β-trihydroxyolean-12-en-28-oic acid (118) (4%), and the known metabolite, 2α,3β-
dihydroxyolean-12-en-28-oic acid (119) (3%) [Figure 27]. Compounds 117 (IC = 12.8 ± 0.00 μM), 118
[43]
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(IC = 444.0 ± 8.0 μM), and 119 (IC = 666.0 ± 20.0 μM) showed a significant α-glucosidase inhibitory
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activity, as compared to the standard, drug acarbose (IC = 780.0 ± 0.28 μM).
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Biotransformation of 18-glycyrrhetinic acid (120)
Biotransformation of 18-glycyrrhetinic acid (120) with Cunninghamella elegans yielded the metabolite, 3, 7-
dihydroxy-11-oxo-olean-12-en-30-oic acid (121) (4%), while fermentation of 120 with Fusarium lini