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Author Instructions

            Perspective  A Perspective provides personal   2000max Unstructured abstract.   3-6   /
                         points of view on the state-of-the-  No more than 150 words. keywords.
                         art of a specific area of knowledge
                         and its future prospects.
            Opinion      An Opinion usually presents   2500max Unstructured     3-8      /
                         personal thoughts, beliefs, or     abstract (optional).No  keywords.
                         feelings on a topic.               more than 250 words.
           2.3 Manuscript Structure
           2.3.1 Front Matter
           2.3.1.1 Title
           The title of the manuscript should be concise, specific and relevant, with no more than 16 words if possible. When gene or
           protein names are included, the abbreviated name rather than full name should be used.

           2.3.1.2 Authors and Affiliations
           Authors’ full names should be listed. The initials of middle names can be provided. Institutional addresses and email
           addresses for all authors should be listed. At least one author should be designated as corresponding author. In addition,
           corresponding authors are suggested to provide their Open Researcher and Contributor ID upon submission. Please note
           that any change to authorship is not allowed after manuscript acceptance.

           2.3.1.3 Highlights
           Highlights are mandatory because they can help increase the discoverability of your article through search engines. They
           consist of a short collection of bullet points that capture the novel results of your research as well as new methods that were
           used during the study (if any). They should be submitted in a separate editable file in the online submission system. Please
           use ‘Highlights’ in the file name and include 3 to 5 bullet points (maximum 85 characters per bullet point, including spaces).
           2.3.1.4 Abstract
           The abstract should be a single paragraph with word limitation and specific structure requirements (for more details please
           refer to Types of Manuscripts). It usually describes the main objective(s) of the study, explains how the study was done,
           including any model organisms used, without methodological detail, and summarizes the most important results and their
           significance. The abstract must be an objective representation of the study: it is not allowed to contain results which are not
           presented and substantiated in the manuscript, or exaggerate the main conclusions. Citations should not be included in the
           abstract.

           2.3.1.5 Graphical Abstract
           The graphical abstract is essential as this can catch first view of your publication by readers. We recommend you to submit
           an eye-catching figure. It should summarize the content of the article in a concise graphical form. It is recommended to use
           it because this can make online articles get more attention. The graphic abstract should be submitted as a separate document
           in the online submission system. Please provide an image with a minimum of 531 × 1,328 pixels (h × w) or proportionally
           more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types:
           tiff, psd, AI, jpeg and eps files.
           2.3.1.6 Keywords
           Three to six keywords should be provided, which are specific to the article, yet reasonably common within the subject
           discipline.

           2.3.2 Main Text
           Manuscripts of different types are structured with different sections of content. Please refer to Types of Manuscripts to
           make sure which sections should be included in the manuscripts.
           2.3.2.1 Introduction
           The introduction should contain background that puts the manuscript into context, allow readers to understand why the
           study is important, include a brief review of key literature, and conclude with a brief statement of the overall aim of the
           work and a comment about whether that aim was achieved. Relevant controversies or disagreements in the field should be
           introduced as well.

           2.3.2.2 Experimental
           Experimental should contain sufficient details to allow others to fully replicate the study. New methods and protocols
           should be described in detail while well-established methods can be briefly described or appropriately cited. Experimental
           participants selected, the drugs and chemicals used, the statistical methods taken, and the computer software used should be
           identified precisely. Statistical terms, abbreviations, and all symbols used should be defined clearly. Protocol documents for
           clinical trials, observational studies, and other non-laboratory investigations may be uploaded as supplementary materials.

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