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Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02 Page 17 of 50
Figure 28. Microbial transformation of 18-glycyrrhetinic acid (120) with Cunninghamella elegans, and Fusarium lini.
Figure 29. Microbial transformation of testosterone (123) with Curvularia lunata, Pleurotus oestreatus, Rhizopus stolonifer, and Fusarium
lini.
derivatives, 17β,11α-dihydroxy-androst-4-en-3-one (130) (0.6%), 17β,11α-dihydroxy-androst-1, 4-dien-3-
one (131) (1.2%), 11α-hydroxy-androst-1, 4-dien-3,17-dione (132) (3.1%), and androst-1, 4-dien-3, 17-dione
[46]
(133) (2.5%) [Figure 29] [Proposed Supplementary Figure 6].
Biotransformation of dihydrotestosterone (134)
Four derivatives, 1α-hydroxy-androst-1, 4-dien-3, 17-dione (132) (2.2%), and androst-1, 4-dien-3, 17-dione
(133) (2.4%), 17β-hydroxyandrosta-1, 4-dien-3-one (135) (1.9%) [Supplementary Figure 5], and 7α, 17β-di-
hydroxyandrosta-1, 4-dien-3-one (136) (1.6%), were synthesized via Fusarium oxysporum-mediated
transformation of the male steroidal hormone dihydrotestosterone (134) [Figure 30] [Proposed
[47]
