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Page 8 of 50 Siddiqui et al. Chem Synth 2023;3:25 https://dx.doi.org/10.20517/cs.2023.02
Figure 8. Biotransformation of (-)-isolongifolol (41) with Fusarium lini.
Figure 9. Biotransformation of 5α-hydroxycaryophylla-4(12), 8(13)-diene (45) with Macrophomina phaseolina.
Figure 10. Biotransformation of (-)-caryophyllene oxide (49)with Catharanthus roseus
oxide (52) (3.2%), and 4, 5-epoxycaryophyllan-8 (13) -en-14-ol (55) (4.6%) [Figure 11]. Moreover, four
[31]
new derivatives, 4, 5-epoxy-13-norcaryophyllan-8-one (56) (2.5%), caryolane-5, 8, 13-triol (57) (2.3%),
clovane-5, 9, 12-triol (58) (2.1%), and 4, 5-epoxycaryophyllan-3, 13-diol (59) (2.1%), were also synthesized
by our research group through the biotransformation of (-)-caryophyllene oxide (49) with Rhizopus
[31]
stolonifer, Aspergillus niger, Gibberella fujikuroi, and Fusarium lini, respectively [Figure 12].
