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Shalimova Cardiovascular remodeling in EH and DM2

DISCUSSION pronounced cardiovascular remodeling compared to
the A/A genotype. Patients with the Pro/Pro genotype
Changes in echocardiographic parameters depending of the Pro12Ala polymorphism of PPARγ2 had more
on genetic polymorphisms of the AGTR1 gene can severe hemodynamic and metabolic disorders.
be regarded as a result of varying activation of AT1
receptors, leading to differential expression and Authors’ contributions
proliferation of cardiomyocytes and myocardium A. Shalimova contributed solely to this paper.
remodeling. [14,15]
Financial support and sponsorship
The involvement of polymorphisms of the AGTR1 gene None.
in the development and progression of atherosclerotic
processes was demonstrated by significantly lower Conflicts of interest
levels of anti-atherogenic high density lipoprotein There are no conflicts of interest.
cholesterol and significantly higher levels of glucose,
HbA1c, insulin and HOMA-IR in patients with the A/C Patient consent
+ C/C genotype compared to the A/A genotype. More Each patient was informed the study and gave their
pronounced IR in the A/C + C/C genotype can be consent.
explained by common mechanisms of hypertension
and IR, including activation of the renin-angiotensin- Ethics approval
aldosterone system, which affects the sensitivity of The study protocol was supported by the Ethics
tissues to insulin and compensatory hyperinsulinemia. Committee of the Kharkiv National Medical University.

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