Page 91 - Read Online

Shalimova. Vessel Plus 2017;1:84-90 Vessel Plus
DOI: 10.20517/2574-1209.2016.08
www.vpjournal.net
Short Communication Open Access

Heart and vascular remodeling in essential

hypertension and type 2 diabetes is

dependent on genetic polymorphisms

Anna Shalimova

Kharkiv National Medical University, Kharkiv 61022, Ukraine.
Correspondence to: Dr. Anna Shalimova, Kharkiv National Medical University, 4 Nauky Avenue, Kharkiv 61022, Ukraine.
E-mail: annashalimova@yandex.ua

How to cite this article: Shalimova A. Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic
polymorphisms. Vessel Plus 2017;1:84-90.

Dr. Anna Shalimova was graduated from Kharkiv National Medical University in 2005. Her medical specialties
are Internal Medicine, and General Practice - Family Medicine. In 2010 she defended the PhD-thesis “The
mechanisms of the development chronic heart failure in patients with chronic kidney disease”. In 2016 she
defended the Doctoral thesis “The role of genetic, hemodynamic and metabolic mechanisms in the development
of comorbid pathology - essential hypertension and type 2 diabetes”. She is the author and co-author of
publications by hypertension and diabetes indexed in Pubmed and SCOPUS. Now she is responsible for research
work in Clinical Pharmacology Department at Kharkiv National Medical University.

ABSTRACT
Article history: Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant
Received: 22-10-2016 type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II
Accepted: 29-12-2016 receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2).
Published: 27-06-2017 Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood
flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results:
Key words: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more
Essential hypertension, pronounced metabolic disorders, a larger left ventricle (LV), higher myocardial mass index
type 2 diabetes comorbidity, left ventricle, and a greater intima media thickness (IMT), with a lower rate of endothelium-
genetic polymorphism, dependent vasodilation (EDVD) compared to the A/A genotype. Patients with the Pro/Pro
heart and vascular remodeling genotype of PPARγ2 had higher levels of blood pressure, larger LVs, greater IMT, pulse wave
velocity, and a lower rate of EDVD compared to the Pro/Ala and Ala/Ala genotypes. Patients
with the Pro/Pro genotype had significantly more pronounced dyslipidemia and insulin
resistance than patients with other PPARγ2 genotypes. Conclusion: The polymorphism of
genetic markers AGTR1 and PPARγ2 in patients with EH and concomitant DM2 was associated
with the development of comorbidity. Different genotypes of specific genes alter the severity of
cardiovascular remodeling and metabolic disorders.

Quick Response Code:
This is an open access article licensed under the terms of Creative Commons Attribution 4.0 International
License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution,
and reproduction in any medium, as long as the original author is credited and the new creations are licensed under the
identical terms.
For reprints contact: service@oaepublish.com

84 © 2017 OAE Publishing Inc. www.oaepublish.com