Page 209 - Read Online

Wang et al. Vessel Plus 2017;1:202-12 Vessel Plus
DOI: 10.20517/2574-1209.2017.29
www.vpjournal.net
Review Open Access

Adipose tissue-derived cytokines, CTRPs

as biomarkers and therapeutic targets

in metabolism and the cardiovascular

system

Ya-Jing Wang , Jian-Li Zhao , Wayne Bond Lau , Jing Liu , Rui Guo , Xin-Liang Ma 1,2
2
1,2
2
1,3
1
1 Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
2 Department of Physiology, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
3 Department of Anesthesiology, The First Affiliated Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Correspondence to: Dr. Ya-Jing Wang, Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
E-mail: yajing.wang@Jefferson.edu
How to cite this article: Wang YJ, Zhao JL, Lau WB, Liu J, Guo R, Ma XL. Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic
targets in metabolism and the cardiovascular system. Vessel Plus 2017;1:202-12.

ABSTRACT
Article history: Increasing evidence indicates that adipose tissue-originated cytokines mediate communication
Received: 4 Aug 2017 between obesity-related exogenous molecules and the molecular events that initiate the
First Decision: 12 Sep 2017 metabolic syndrome and the inflammatory responses in the cardiovascular system (CVS).
Revised: 1 Oct 2017 Adipose tissue-derived cytokines including the C1q/tumor necrosis factor-related proteins
Accepted: 21 Oct 2017 (CTRPs), a 15-member family of novel adipokines, has attracted much interest due to its
Published: 28 Dec 2017 metabolic regulatory and anti-inflammatory effect and appear to play a pathophysiological
role in metabolism and immunity. To date, 15 members of CTRP family have been identified
Key words: and they also play a role in the CVS, especially as potent biomarkers or therapeutic targets
Adipose tissue-derived cytokines, for modulating metabolic or inflammatory functions. Therefore, this review will focus on the
adipokines, characteristics of CTRPs that influence cardiovascular function and on the potential of CTRPs
C1q/tumor necrosis factor-related as biomarkers and therapeutic targets.
proteins,
metabolism,
cardiovascular system,
biomarker,
therapeutic target

INTRODUCTION obesity, and the inflammatory processes. By acting
systemically as circulating hormones or locally on
During the last decade, a mounting number of diverse cell types, adipokines are involved in the
adipocyte-originated hormones (adipokines) have regulation of many physiological functions, including
been recognized and documented to be discriminately energy storage, metabolism, and the development of
regulated during the onset of metabolic syndrome, obesity-associated disorders (type 2 diabetes mellitus,

Quick Response Code:
This is an open access article licensed under the terms of Creative Commons Attribution 4.0 International
License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution,
and reproduction in any medium, as long as the original author is credited and the new creations are licensed under the
identical terms.
For reprints contact: service@oaepublish.com

202 © The Author(s) 2017 www.oaepublish.com