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Bilovol et al. Vessel Plus 2017;1:196-201 Vessel Plus
DOI: 10.20517/2574-1209.2017.17
www.vpjournal.net
Topic: Atherosclerosis and Related Diseases Open Access

Relationship between peculiarities of

atrial fibrillation, body mass index and

adipokines levels

Oleksandr Bilovol, Yuliya Shaposhnikova, Iryna Ilchenko, Anna Shalimova

Kharkiv National Medical University, Department of Internal Medicine and Clinical Pharmacology, Kharkiv 61022, Ukraine.
Correspondence to: Dr. Anna Shalimova, Kharkiv National Medical University, Department of Internal Medicine and Clinical Pharmacology, Kharkiv
61022, Ukraine. E-mail: anna.shalimova83@gmail.com

How to cite this article: Bilovol O, Shaposhnikova Y, Ilchenko I, Shalimova A. Relationship between peculiarities of atrial fibrillation, body mass
index and adipokines levels. Vessel Plus 2017;1:196-201.

ABSTRACT
Article history: Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting
Received: 8 Jun 2017 development of atrial fibrillation (AF) in the general population. Methods: Three hundred
Accepted: 11 Sep 2017 and ninety eight patients were examined for the presence of phenotype metabolically healthy
Published: 28 Dec 2017 obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme
immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal
Key words: monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and
Atrial fibrillation, 42.0% of participants; while 21.1% were normal body weight (group 3) and 13.1% had a BMI
obesity, < 19.9 kg/m² (group 4). Phenotype MHO was detected in 19.6% patients. At follow-up, 32.4%
metabolically healthy obesity, of participants developed AF. Adiponectin levels were significantly higher in MHO patients as
metabolically unhealthy obesity,
serum leptin, compared to metabolically unhealthy patients with abdominal obesity (AO). High molecular
high-molecular-weight adiponectin weight adiponectin (HMVAN) levels were significantly decreased in patients of groups 1 and
4, as compared to groups 2 and 3. Correlation between AF and HMWAN was determined by
regressive analysis in patients of 1st and 4th groups (β = -0.24, P = 0.003 and β = -0.26, P =
0.002, respectively). Conclusion: The probability of developing AF increases with AO and
decreased BMI, which is accompanied by a change in HMVAN levels. In MHO patients, the
probability of AF developing is identical with persons having normal BMI.

INTRODUCTION and mortality. It can be explained by advances in the
treatment of coronary heart disease (CHD) and heart
The likelihood of being overweight or obese in failure (HF) improving life expectancy and consequently
adulthood has been increasing in epidemic proportions the prevalence of AF (since the incidence of atrial
in the last few decades . We have witnessed a parallel fibrillation increases with age) .
[1]
[2]
rise in the incidence of atrial fibrillation (AF), which is
the most common sustained cardiac arrhythmia and Abdominal obesity (AO) and excess body weight are
a significant cause of cardiovascular (CV) morbidity associated with the development of cardiovascular

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