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Nikiforov et al. Vessel Plus 2017;1:192-5 Vessel Plus
DOI: 10.20517/2574-1209.2017.21
www.vpjournal.net
Topic: Atherosclerosis and Related Diseases Open Access

Proinflammatory monocyte polarization

in type 2 diabetes mellitus and coronary

heart disease

Nikita G. Nikiforov 1,2,3 , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova ,
4
1
4
4
Ekaterina A. Ivanova 5
1 Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
2 Institute of Clinical Cardiology, Russian Cardiology Research and Production Complex, Ministry of Healthcare, 121552 Moscow, Russia.
3 Institute for Atherosclerosis Research, Skolkovo Innovation Center, 121609 Moscow, Russia.
4 Sechenov’s First Moscow State Medical University, 119992 Moscow, Russia.
5 Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
Correspondence to: Dr. Ekaterina A. Ivanova, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium.
E-mail: kate.ivanov@gmail.com

How to cite this article: Nikiforov NG, Galstyan KO, Nedosugova LV, Elizova NV, Kolmychkova KI, Ivanova EA. Proinflammatory monocyte
polarization in type 2 diabetes mellitus and coronary heart disease. Vessel Plus 2017;1:192-5.

ABSTRACT
Article history: Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis.
Received: 10 Jun 2017 There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the
Accepted: 20 Sep 2017 relationship between the development of atherosclerotic plaque formation and the amount
Published: 28 Dec 2017 of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the
ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart
Key words: disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in
Type 2 diabetes mellitus, vitro. Results: Increased levels of basal and stimulated secretion of tumor necrosis factor alpha
coronary heart disease, (TNF-α) was observed in diabetic patients compared with healthy subjects. On the contrary,
M1/M2 monocyte polarization,
oxidative stress, in patients with CHD, decreased secretion of the pro-inflammatory cytokine, TNF-α, was
atherosclerosis, found. A direct correlation between glycated hemoglobin (HbA1c) levels in T2DM patients
inflammatory and basal secretion of TNF-α from monocytes was observed. Conclusion: The authors found
diametrically different responses of monocytes from T2DM and CHD under pro-inflammatory
stimuli.

INTRODUCTION Т2DM patients are more likely to exhibit an accelerated
development of atherosclerosis and have a 3-4-
[2]
Increased prevalence of type 2 diabetes mellitus fold increased risk for cardiovascular mortality .
(T2DM) around the globe has been deemed a “non- Hyperglycemia is currently considered the main culprit
infectious epidemic” and according to the International for vascular lesion progression. A meta-analysis of 20
Diabetes Federation, it is predicted that the number different studies involving 95,783 patients, followed
of patients with T2DM will reach 642 million people by for 12 years, led to the conclusion that glucose is the
2040 . common underlying risk factor for atherosclerosis,
[1]
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