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Nikiforov et al. Proinflammatory monocyte polarization in T2DM and CHD

of chronic inflammation. Unexpectedly, we found Nedosugova LV, Kaminnyi AI, Tikhaze AK, Ageev FT, Kukharchuk
diametrically different abilities of monocytes from T2DM VV, Belenkov YN. Oxidative stress in atherosclerosis and diabetes.
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Lerman A. Local production of lipoprotein-associated phospholipase
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Authors’ contributions 8. Tousoulis D, Davies G, Stefanadis C, Toutouzas P, Ambrose JA.
Concept and performed experimental studies, general Inflammatory and thrombotic mechanisms in coronary atherosclerosis.
coordination, supervision of the research projectand Heart 2003;89:993-7.
wrote the manuscript: N.G. Nikiforov 9. Bonizzi G, Karin M. The two NF-kappaB activation pathways
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Clinical examination and clinical data acquisition: K.O. 10. Lawrence T, Gilroy DW. Chronic inflammation: a failure of resolution?
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Galstyan 11. MantovaniA,Sozzani S, Locati M, Allavena P, Sica A. Macrophage
Cell culture experiments: N.V. Elizova, K.I. Kolmychkova polarization: tumor-associated macrophages as a paradigm for
Manuscript editing: E.A. Ivanova polarized M2 mononuclear phagocytes. Trends Immunol 2002;2:549-
55.
Financial support and sponsorship 12. Arzamastseva NE, Lankin VZ, Konovalova GG, Tikhaze AK, Ageev
This work was supported by Russian Science FT, Lapina YV, Narusov OY, Mareev VY, Belenkov YN. Oxidative
stress in patients with chronic heart failure and type 2 diabetes mellitus.
Foundation (Grant # 14-15-00112). Bull ExpBiol Med 2007;143:207-9.
13. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin
Conflicts of interest Invest 2005;115:1111-9.
There are no conflicts of interest. 14. Neels JG, Olefsky JM. Inflamed fat: what starts the fire? J Clin Invest
2006;116:33-5.
Patient consent 15. Sobenin IA, Galitsyna EV, Grechko AV, Orekhov AN. Small dense and
All participants gave their written informed consent desialylated low density lipoprotein in diabetic patients. Vessel Plus
2017;1:29-37.
prior to their inclusion in the study. 16. Fernandez-Real JM, Ricart W. Insulin resistance and chronic
cardiovascular inflammatory syndrome. Endocr Rev 2003;24:278-301.
Ethics approval 17. Xia P, Inoguchi T, Kern TS, Engerman RL, Oates PJ, King GL.
It was approved by the local ethics committee of Characterisation of the mechanism for the chronic activation of
the Institute for Atherosclerosis Research, Skolkovo diacylglycerol-protein kinase C in diabetes and hypergalactosaemia.
Innovation Center, Moscow, Russia. Diabetes 1994;43:1122-9.
18. Ceolotto G, Gallo A, Miola M, Sartori M, Trevisan R, Del Prato S,
Semplicini A, Avogaro A. Protein kinase C activity is acutely regulated
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