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Myasoedova et al. Vessel Plus 2017;1:96-7 Vessel Plus
DOI: 10.20517/2574-1209.2017.22
www.vpjournal.net
Topic: Atherosclerosis and Related Diseases Open Access

A prominent role of D-dimer in inflammation

and atherosclerosis

Veronika A. Myasoedova , Paolo Poggio , Alessandro Parolari 2,3
1
1
1 Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
2 Policlinico San Donato IRCCS, Unità Operativa di Cardiochirurgia e Ricerca Traslazionale, San Donato Milanese, 20097 Milan, Italy.
3 Dipartimento di Scienze Biomediche per la salute, University of Milan, 20133 Milan, Italy.
Correspondence to: Dr. Veronika A. Myasoedova, Centro Cardiologico Monzino, IRCCS, Via Carlo Parea 4, 20138 Milan, Italy.
E-mail: veronika.myasoedova@gmail.com

How to cite this article: Myasoedova VA, Poggio P, Parolari A. A prominent role of D-dimer in inflammation and atherosclerosis. Vessel Plus
2017;1:96-7.

Article history: Received: 15 Jun 2017 Accepted: 9 Aug 2017 Published: 26 Sep 2017

Plasma D-dimer (D-d) is a product of plasmin evident when PET results were combined with D-d
fibrinolysis of cross-linked fibrin that leads to increased levels.
fibrin turnover. D-d is a known biomarker of coagulation
and is commonly used for quick diagnosis of deep These data suggest that, after acute cardiac states,
venues thrombosis, pulmonary embolism and acute the combination of D-d and CRP levels appears to be
aortic syndrome, with high sensitivity and rather low a strong predictor of cardiovascular events and overall
specificity. Recent data suggest that D-d is helpful for mortality.
[1]
both diagnostic and prognostic purposes.
The role of systemic inflammation in all stages
Mori et al. evaluated the potential of D-d and of atherosclerosis is well known. Based on D-d
[2]
C-reactive protein (CRP) levels, measured at hospital association with inflammation, we evaluated the role
of this circulating biomarker in patients that underwent
admission, to predict long-term adverse events after coronary artery bypass grafting (CABG). The specific
[4]
acute aortic dissection. They showed that patients with aim of this study was to assess if D-d level, before
the worst outcomes had both biomarkers elevated surgery, was able to predict graft occlusion. Eighteen
compared to patients with no or minor adverse events. months after CABG, we evaluated graft patency by
CT scanning. Notably, pre-operative D-d level was
In another study by Gorla et al., the results obtained an independent predictor for both arterial and venous
[3]
by evaluation of inflammatory imaging markers with grafts occlusion.
flurodeoxyglucose positron emission tomography -
computed tomography (FDG PET CT) and adverse D-d was identified also as a predictor of atherosclerotic
outcomes, during a 3-year follow-up after acute aortic lesion severity and of overall outcomes in 2209
syndrome, suggested that all-cause mortality and angiographically-proven patients with coronary artery
major adverse events were higher in the PET-positive disease (CAD). In addition, in a large prospective
[5]
patients. Interestingly, these differences were more study, D-d measured at baseline was shown to

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