Page 78 - Read Online

Page 10 of 12 Luo et al. Soft Sci 2024;4:7 https://dx.doi.org/10.20517/ss.2023.40

Cu O + O + e → Cu O + O 2 - (5)
-
2
2
2
O + H O → H O + ·OH (6)
-
2
2
2
2
O + H O → H O + ·OH + O 2 (7)
-
2
2
2
2
·OH + glucose → glucolactone (8)
Then, the electrons produced by the electrochemical oxidation of glucose were transferred to the external
circuit through the working electrode, which generated a current signal. As discussed above, cuprous oxide
enhanced the electrocatalytic activity of the ACO electrode by producing O and ·OH, leading to glucose
-
2
oxidation at negative potentials.
CONCLUSIONS
In sum, we proposed a novel approach to prepare a highly sensitive, non-enzyme-based electrode with good
selectivity for electrochemical glucose sensing by directly printing Ga-LM on an ITO or PE substrate and
realizing galvanic replacement in situ growth of cuprous oxide on Ga-LM. The characterizations and
electrochemical measurements of the as-prepared electrode revealed the successful fabrication of cuprous
oxide, and the proposed electrode can potentially be applied in enzyme-free electrochemical sensing
schemes. Owing to mechanical and electrical synergy of the ACO, the ACO electrode exhibited high
sensitivity in the glucose detection over a wide glucose concentration range of 1 μM-10 mM. In addition, the
sensor exhibited a low detection limit and good selectivity for glucose. The glucose sensor fabricated herein
has great potential for use in the detection of human serum glucose, dietary glucose, and clinical diagnoses.

DECLARATIONS
Authors’ contributions
Made substantial contributions to the conception and design of the study: Ren L, Liao G
Performed data analysis and interpretation and wrote the manuscript: Luo Y, Liao G, Guo Z
Provided administrative, technical, and material support: Qi X, Ren L, Huang Z

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by Grants from the National Natural Science Foundation of China (No. 52201164,
No. 12274359), Fundamental Research Funds for the Central Universities (WUT: 2022IVA187), Natural
Science Fund for Distinguished Young Scholars of Hunan Province (No. 2023JJ10037), Scientific Research
Fund of Hunan Provincial Education Department (No. 21B0128), and Postgraduate Scientific Research
Innovation Project of Hunan Province (No. CX20230548).

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.