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Jun Multipotency and secretome of ADSC

multi-lineage cells isolated from adipose tissues Financial support and sponsorship
called stromal vascular fractions, which are assumed None.
to be stem cells and named the cells “processed
lipoaspirate.” Lately, these “processed lipoaspirate” Conflicts of interest
cells have come to be called adipose tissue-derived
stromal cells, or adipose tissue-derived stem cells There are no conflicts of interest.
(ASCs). [4,5] These cells, after being extracted and
separated from adipose tissue, show stable growth Patient consent
and proliferation in culture environments, and have the Not applicable.
capability of differentiating into various cell types, just
like marrow stem cells. [6] Ethics approval

Not applicable.
The authors reviewed 118 articles regarding ASCs using
PubMed and Cochrane databases. They summarized:
(1) immunophenotypic properties; (2) cellyield; (3) REFERENCES
angiogenic effect; (4) effects on wound healing; and
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[6]
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ability of mesenchymal stem cells to differentiate has 28.
been also reported to vary according to the tissue of 4. Hattori H, Sato M, Masuoka K, Ishihara M, Kikuchi T, Matsui
origin, or the donor’s age. However, the theory that T, Takase B, Ishizuka T, Kikuchi M, Fujikawa K, Ishihara M.
[7]
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may affect the characteristic of differentiation is not yet 5. an alternative stem cell source. Cells Tissues Organs 2004;178:2-12.
Rodriguez AM, Elabd C, Delteil F, Astier J, Vernochet C, Saint-Marc
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In the authors’ paper, ASCs have the ability to tissue. Biochem Biophys Res Commun 2004;315:255-63.
differentiate into several cell lineages, improve wound 6. Jun YJ, Rhie JW, Choi YS, Kim YJ, Kim SE, Lee JI, Han KT. The
healing, and promote angiogenesis. I believe this effects of adipose derived stem cells on neurogenic differentiation and
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Authors’ contributions Chen H, Mao Q, Chen D. Comparative analysis of mesenchymal stem
cells fromadult mouse adipose, muscle, and fetal muscle. Mol Biol
Y.J. Jun contributed solely to the paper. Rep 2013;40:885-92.

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