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Rajput                                                                                                                                                                                Cyclical nutritional therapy clinical trial

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                                                                                     Hair density in treatment group
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             30                                                                      Hair density in control group


             20                                                                      Non responders in control group


             10

             0
                 2 months       4 months        6 months       12 months
           Figure 3: Hair density in men


           significant with P-value 0.00038. Patients with temporal   average improvement in density was 9% and the
           angle receding and thinning also responded well to   average calibre improved by 7%. At 1 year, the hair
           cyclical medicine [Figure 7]. Maximum improvement in   calibre had improved 11% while at the end of 1 year
           hair density in 1 of the women was 112%. Improvement   the maximum density had improved 14%. There were
           in hair calibre was 33% at 6 months and 58% by the   45% patients with no change in density or calibre at
           end of 1 year [Figure 8].                          6 months - this number was reduced to 42% non-
                                                              responders at the end of 1 year.
           In the control group CM for men, 76% patients had
           no response in the initial 2 months and 62% had no   In the control group CW for women, density improved
           response even at 4 months with 2% minoxidil and    by 3% in 2 months and 4% in 4 months, 56% females
           1 mg finasteride every day. The density improved   had no improvement at all at 2 months. Density
           by an average 2% at 2 months and 4% at 4 months.   improved by an average of 1.5% in 2 months and
           Hair calibre measured on folliscope, was 2% better   3.5% in 4 months. Calibre was unchanged in 60%
           at 2 months and 3% at 4 months. There were 48%     patients, it was 2% better at 2 months and 3% at 4
           patients having no improvement at all in either density   months, with 38% patients still having no improvement
           or calibre at the end of 4 months. At 6 months the   at all in density or calibre. At 6 months, the average


            A                                B                                C
















           Figure 4: A: crown area grade V baldness day one before starting treatment; B: improvement over crown area after 2 months of nutritional
           correction and 2% minoxidil; C: regrowth in grade V baldness over crown area in 6 months without finasteride
                           Plastic and Aesthetic Research ¦ Volume 4 ¦ September 30, 2017                 167
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