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Rajput Cyclical nutritional therapy clinical trial

unusual organ that grows when cells in the body are Exclusion criteria: (1) patients who had previously tried
allowed to die. Hair is created when the piling up of any kind of hair loss treatment within the last 6 months,
dead keratinized cells are serially pushed upwards were excluded; (2) patients who were on any kind of
while new dead cells are generated from below. Keratin supplements, protein shakes, medical treatment for
deposition in the cells gradually increases as the cells any condition were excluded; (3) patients with regular
are pushed towards the outer layers of the skin, finally alcohol intake and smokers were excluded; (4) male
the cells become non-viable, dead cells pile up over patients with Norwood Hamilton grade I and grade II
one another and are pushed out of the body in the form hair loss and female patients with Ludwig grade I hair
of hair and nails. Saturation of the body with vitamins, loss were excluded.
especially vitamin A [61,62] , vitamin E [63-65] , Omega
three fatty acids [66] become pro oxidant, interfere with Control group for men (CM) and control group for
keratinisation leading to non-creation of hair keratinized women (CW): CM consisted of 100 volunteer male
cells ultimately manifesting as hair loss instead of hair patients who were between 25 to 50 years of age
growth. and had hair loss between Norwood Hamilton grade
III to grade V. The male control group received 1 mg
It should be highlighted that the recommended daily finasteride every day and application of 2% minoxidil
allowance (RDA) of various nutrients was decided by a lotion 2 times a day, 1 mL in the morning after bath
discussion and consensus between random selected and 1 mL in the evening before sleep every day.
committees to meet requirement of the rations
supplied to soldiers and industrial workers rather than Control group for women consisted of 100 volunteer
by following experimental analysis of the metabolic female patients who were between 25 to 50 years
requirements within the human body [67] . Nutrients and of age and had hair loss Ludwig grade II and III. The
vitamins have two kinds of doses. A therapeutic dose female control group did not receive finasteride, but
given to patients suffering disease due to deficiency were prescribed the application of 2% minoxidil lotion
of the selected nutrient - which does is very high. 1 mL, 2 times a day, morning after bath and evening
A prophylactic or preventive dose to promote good before sleep.
health that can be as low as possible [68] . Part of the Treatment group for men (TM) and treatment group
nutrients could come through diet while part via a low for women (TW): Treatment groups for both men and
dose supplement.
women followed the same protocol. Patients in both
Aims and objectives the groups did not receive finasteride. Both men and
women treatment group applied 2% minoxidil lotion
To test the hypothesis that stimulation of hair 1 mL, 2 times a day, morning after their shower/bath
growth and supporting cell division with nutritional and again in the evening prior to sleep. In addition,
supplements can result in hair growth, without the they received nutritional supplements which included
need to use antiandrogens or enzyme blockers in both antioxidants, vitamins, minerals, omega 3, amino acids
men and women. and biotin. In order to avoid inter nutrient interactions,
improve absorption and have better efficiency we
METHODS planned to have these supplements in synergistic
combinations over a 3 day cycle [Table 3].
Patient selection
Male and female patients between the ages of 25 to 50 Method of hair care and use of nutritional supplements
years, requiring treatment for hair loss, were explained
the nature of the study. Patients made their choice to Table 1: Age distribution of the patients in the study, (%)
have treatment with finasteride and minoxidil or follow Age (years) Male Female
minoxidil with the low dose once in 3 days supplement 25-30 32 36
program. A total 400 patients (200 men and 200 30-40 47 40
women) agreed to choose the standard therapy or 40-50 21 24
accept the nutritional therapy for a commitment of 1
year, were selected to form the control group and the Table 2: Grade of hair loss in male patients, (%)
treatment group with a total of 100 patients per group. Control group Treatment group
The age distribution of male and female patients in the Grade III 30 32
study is displayed in Table 1. We have attempted to Grade IV 50 48
have patients with comparable age and comparable Grade V 20 20
grades of hair loss in the control groups and treatment Ludwig II 48 46
groups as displayed in Tables 1-3. Ludwig III 52 54
164 Plastic and Aesthetic Research ¦ Volume 4 ¦ September 30, 2017