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Rajput Cyclical nutritional therapy clinical trial

We developed a 3 day cycle to utilize 6 supplement concern. With the computerized folliscope analysis we
formulations, in combinations that do not interfere with measured hair growth in terms of density per square
the efficiency of one another and could be synergistic centimetre and hair calibre in microns. The counts and
in action. The patients also felt that they were not calibre were recorded on day one and repeated every
taking too many medicines at one time - a simple 2 months for the 1 year period of study.
2 per day. Patients who had a light or no breakfast
were permitted to have the supplements after lunch. Villus hair count
Patients who felt heaviness in the stomach could take Villus hair counts were recorded initially and compared
1 supplement after lunch and one after dinner. All over 2-month intervals for 1 year. The attempt was
patients applied minoxidil 2% 1 mL in the morning and to correlate if such a method allows to determine the
1 mL in the evening every day. conversion of villus hair to terminal hair during the
treatment period.
Scalp hygiene
All patients in all groups were advised regular Self-evaluation
shampoo 3 times a week. Removing dirt, grime, scalp Patients also had a self-evaluation score at the end
secretions were considered important in facilitating of 1 year. Self-assessment score were designed to
better hair growth. record the personal response of the patients within
the study. Scores were allotted to control of hair loss,
Evaluation of hair regrowth by global appearance of new hair growth, change is the size
photography of the bald spot and difference noticed by friends
All patients had standard photographic views with a and family. Zero score was allotted for no change
12 megapixel digital camera in a fixed, designated and negative score for deterioration of the area. An
place with identical settings, the same light, same assessment score of 4 was satisfactory and 5 was
flash, same distance and same camera. Photographs considered good. A score of 3 was average and below
were taken at day 1, then every 2 months to record 3 was considered poor [Table 4].
the progress for 1 year. Before and after photographs Patients were inquired about sexual side effects, loss
taken, in 5 standard views as front hairline, vertex with of libido, decreased volume of semen, softer erections,
head bent forward, right side, left side and occipital gloomy feeling and difficulty to focus on the task or the
whorl area. Analysis of the photographs were done feeling of disinterest. Patients were requested to report
by 4 different evaluators who were blind to the patient any other concerns, as number of hair falling per day,
profile and patient group. The criteria selected in order dandruff or itching.
to evaluate in the photographs, were hair quality,
hair density or fullness, reduction of bald area and
new hair growth. The improvement was graded from RESULTS
grade I to grade V as I - no change, II - marginal Reduction of hair fall
change or barely noticeable change, III - noticeable
improvement, IV - good improvement and V - very In both the treatment groups TM and TW 68%
patients reported reduction in hair fall per day within
good improvement.
1 month of commencing the therapy. By the end of 4
Evaluation of hair density and calibre by months 85% patients reported reduced hair loss. The
average improvement did not improve further than
computerized analysis 85% till the end of the study period of 1 year. Result
All patients had computerized folliscope analysis for being statistically significant with P-value 0.019. The
measurement of hair density and calibre at micro remaining 15% patients said the hair loss continued
pigment tattooed, fixed test spots over their perceived to be the same, though it has not increased. In both
area of thinning which was their selected area of most the control groups CM and CW, hair fall continued

Table 3: Cyclical vitamin therapy low dose once in three days, have one each after breakfast odds ratio, one each
after lunch odds ratio, one after lunch and one after dinner
Days of the week Supplement combinations
Monday & Thursday Antioxidant, calcium, vitamin D3, magnesium
Tuesday & Friday Iron, folic acid, vitamin C & omega 3
Wednesday & Saturday (Sunday - no medicines) Essential aminoacids, B - complex & biotin
2% Ketoconazole & zinc pyrithione shampoo
Wet your hair, massage the shampoo into the scalp, keep for 3 min & wash, once in 3 - days
Minoxidil 2% solution - 1mL morning & 1mL evening - everyday
Plastic and Aesthetic Research ¦ Volume 4 ¦ September 30, 2017 165