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Rajput Cyclical nutritional therapy clinical trial

response. Similarly patients treated with finasteride do beta 1 (TGFß1) which results in the miniaturization and
not always show the same predictable responses [35-36] , hair loss. Shin et al. [41] followed this research further
some patients do not respond definitively. Reports by with cultured androgen sensitive dermal papilla cells
Kaufman et al. [37] in their long term finasteride study and the addition of DHT to this androgen sensitive cell
have reported that 17% patients have deteriorated caused an accumulation of free radicles ROS within
during their treatment with finasteride. the cultured cells, which in turn induced the release of
TGFß1. The next step of the study was the addition
Hypothesis and the proposed perspective of free radical scavenger N-Acetyl cysteine to the cell
There are numerous causes for hair loss - these culture, that successfully blocked the accumulation
cannot be isolated as singularly responsible, but most of free radicals resulting in successful blockage of
[41]
of the times are working in tandem. We propose that DHT induced secretion of TGFß1 . Therefore,
the approach of cause based on treatment planning we can consider now that antioxidants can prevent
does not work for hair loss. The causes are vague, accumulation of free radicals or reactive oxygen
not quantifiable; are not measurable by any yardstick; species which in turn can neutralize the mechanism
and they cannot be confirmed to have a direct cause of the action of DHT. Vitamin D has direct action
and effect relationship with hair loss. A group of people on induction of hair growth from the dermal papilla.
[42]
[43]
exposed to the same cause do not suffer the same The role of oxidative stress , nutrients, vitamins ,
[44,45]
kind of hair loss, if you try to treat one cause, hair roots minerals , amino acids in maintaining immunity,
[46,47]
being sensitive may fall prey to hair loss from another preventing micro inflammation , and promoting
cause. We should consider the fact that the androgens hair growth has been discussed by several research
or DHT levels in most hair loss patients are normal scientists. The details of the role of non-androgenic
[48]
and not raised [18,23,24] . There are several persons with factors have previously been published .
similar androgen levels who do not have any hair loss
at all. As well as there are other persons who carry the Due to the long term practical use of a hair care
genes, passing them off to the next generation, who program, a more natural alternative solution is
desirable. Cellular turnover and metabolic activity in
do not themselves, manifest any hair loss symptoms. the hair follicles is equivalent to bone marrow and
There are several persons losing hundreds of hair intestinal epithelium therefore, hair growth requires
per day but not going bald because their fallen hair multiple nutrients: antioxidants, amino acids, vitamins,
is regularly replaced with new hair, as the hair cycle minerals and fatty acids [49] . While studying the nutrients
continues [1-3] . Focus should be on the promotion of hair it was highlighted that use of too many supplements at
growth cycles and not on fighting the androgens. The a time, can interfere with the absorption and efficiency
anti-androgenic treatments are required to be used for of one another. Iron and calcium, given together can
a long periods of time, possibly even lifelong. Recent chelate each other and reduce the absorption [50] .
studies by Irwig [38] and Traish et al. [39] highlight the Regular intake of iron can create mucosal blocks to
point that long term use of anti-androgens increases iron absorption [51] , while excess iron can become pro
the possibility of negative side effects that may also oxidant through Fenton reaction [52,53] . Excess cellular
be irreversible. Therefore, it is more scientifically calcium can induce apoptosis of the cells [54] . High
beneficial to strengthen the hair roots, provide a intake of vitamin C does not ensure higher levels in
toxin free environment for the cells and promote hair circulation [55] . High intake of antioxidants reverses the
growth rather than trying to treat a suspected causes benefit and makes them behave as pro oxidants [56] .
that cannot be confirmed. Strengthening the hair and Details of such interaction have been discussed in our
promoting growth can be achieved with vitamins, previous published study [49] .
minerals and nutritional supplements which will deliver
wellness, good health as well as hair growth. The High protein consumed in diet is ultimately digested
falling hair originates from the gradual weakening of to amino acids that enter the circulation, creating
the natural available stock hair roots on the scalp, if a surge that makes the blood pH acidic. The high
these are made strong, the basic source from which acidity requires to be buffered immediately to maintain
falling hair is generated will be blocked preventing homeostasis. Physiologically, calcium is the best
further hair loss. In a sense it would reduce the buffer system in the body. High blood acidity, causes
number of hair falling in every cycle. reabsorption of calcium to buffer the acidic blood,
leading to high calcium levels in the circulation. Kidneys
DHT can be blocked by antioxidants recognise the excess calcium and begin excreting the
An initial experimental study by Eun [40] discovered that calcium leading to a loss of calcium [57-60] - ultimately
DHT does not directly cause inhibition of hair growth causing weakening of hair and bone resulting in
but it induces the release of transforming growth factor hair loss instead of hair growth. We found hair is an

Plastic and Aesthetic Research ¦ Volume 4 ¦ September 30, 2017 163