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Rajput Cyclical nutritional therapy clinical trial

156% over 1 year. Conclusion: Hair loss occurs when weak, sensitive, follicles are affected
trichoscopy, by multiple causes. Hair regrowth can be achieved consistently and safely by strengthening
hair growth, the hair roots and promoting hair growth without necessarily depending on the use of anti
hair loss, androgens.
side effects,
cyclical therapy

INTRODUCTION altered immunity [11,19-22] .
Today, with the understanding of teloptosis and Research workers have attributed the thinning
kenogen by Guarrera et al. [1-3] , patients develop and miniaturization of the hair as the hallmark of
baldness, not due to hair loss but due to the empty androgenic alopecia (AGA). Now numerous other
follicle stage. Patients gradually develop empty bald types of thinning and hair loss have been identified
areas as a result of the falling telogen hair no longer as mimicing AGA [22-25] . Therefore we found the
being replaced with new anagen hair. The physiological need to develop a new category of description and
balance of the hair growth cycle is disrupted [3-6] leading classification defined as diffuse unpatterned hair
to loss of density, gradually manifesting into baldness. loss (DUPA) [8,26] . We now clinically face hair loss
However, patients assume they are balding due to that displays all the characteristics of AGA but does
the visual hair loss and pursue multiple remedies not confirm to genetic predisposition and has no
for control. The loss of 100-150 hair follicles a day family history [27] . AGA can skip siblings and skip
is normal [7,8] in Caucasians. Caucasians have over generations. Though siblings carry the genes, there
a 100,000 hair follicles on the head and losing 150 are more collaborators than just the presence of DHT
follicles a day, or 4,500 in a month, is a loss of less to manifest miniaturization and present the clinical
than 5%. We would draw attention to the fact that, even characteristics of AGA. Works of Headington, Philpott,
after considering individual variation in the total number Farjo N, Farjo B and Bahta have indicated that the
of follicles lost, there would remain 85% to 95% of multiple pathways of hair loss are in fact, interlinked,
follicles which are not in the active fall phase - these overlapping and in over 33% of the cases there may
follicles are available and willing to grow. How can we not be any identifiable cause [6,28] .
make these follicles grow better and healthier? Let us
look at the available knowledge in a new perspective to DHT has been considered to be a cause for hair loss
promote hair growth and achieve better density instead but it is uncommon to find raised DHT levels in patients
of fighting hair fall. and there is no correlation between DHT levels and
the grade of hair loss manifested in the patients [18] .
Various factors affecting hair loss, weaken the hair Under the influence of other known and unknown
roots and make them sensitive to normal levels of factors, even normal androgen levels can lead to hair
androgens in the body [9-12] . Pattern hair loss can occur loss. DHT’s presence is what causes the genes to
with normal androgen levels [12,13] , pattern hair loss express the balding gene and the blood levels alone
can occur before puberty [13-15] , it has been reported do not relate directly to the extent of hair loss. Thus
in hypogonadism [16] and also in a case of complete we say, not a raised DHT but a higher sensitivity of the
androgen insensitivity syndrome [17] . Instead of insisting hair roots is responsible for hair loss [11,29-31] . Studies by
on anti-androgens in management of hair loss patients, Sawaya and Price [32] , on the 5-alpha reductase type
we should focus on strengthening the hair follicle 1, type 2, aromatase and androgen receptors, along
and promoting better hair growth to ensure more with the cutaneous androgen metabolism studies
hair on the head. Eminent research workers Trueb , by Chen et al. [33] and Hoffman and Happle [34] current
[3]
[5]
Klingman , Rook and Dawber in their studies of the understanding of androgenic alopecia, all support
[4]
dynamics of hair growth, have highlighted the fact that the conclusion that sensitivity of the follicles is of
hair loss is a result of dysregulation of the hair growth greater concern than raised levels of androgens. We
cycles or imbalance between factors regulating, hair have discovered a limited correction of one of the
loss and hair growth or to say the factors known to mechanisms for hair loss by blocking conversion of
be, favourable and unfavourable for hair growth. testosterone to DHT but are attempting to treat all the
The same is also emphasised by the studies of various types of hair loss with the same approach.
[6]
[7]
Headington , Paus and Cotsarelis , Liyanage and Minoxidil and finasteride, which to date are the only two
[8]
Sinclair . The role of dihydrotestosterone (DHT) FDA approved and commonly accepted treatments for
levels in hair loss is being questioned [18] . Research hair loss, were both discovered by serendipity and not
and understanding today suggest that hair loss can be by studying the hair loss cycles. Patients treated with
genetic, hormonal, nutritional, inflammatory or due to minoxidil do not always show a predictable standard
162 Plastic and Aesthetic Research ¦ Volume 4 ¦ September 30, 2017