Page 97 - Read Online
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Harry et al. Neuroimmunol Neuroinflammation 2020;7:150-65 I http://dx.doi.org/10.20517/2347-8659.2020.07 Page 165
through phagosomal destabilization. Nat Immunol 2008;9:847-56.
176. Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune
responses and disease pathogenesis. Nat Immunol 2009;10:241-7.
177. Hanamsagar R, Torres W, Kielian T. Inflammasome activation and IL-1beta/IL-18 processing are influenced by distinct pathways in
microglia. J Neurochem 2011;119:736-48.
178. Lunov O, Syrovets T, Loos C, Nienhaus GU, Mailander V, et al. Amino-Functionalized polystyrene nanoparticles activate the NLRP3
inflammasome in human macrophages. ACS Nano 2011;5:9648-57.
179. Schnaars M, Beckert H, Halle A. Assessing β-amyloid-induced NLRP3 inflammasome activation in primary microglia. Methods Mol
Biol 2013;1040:1-8.
180. Hughes MM, O’Neill LAJ. Metabolic regulation of NLRP3. Immunol Rev 2018;281:88-98.
181. Heid ME, Keyel PA, Kamga C, Shiva S, Watkins SC, et al. Mitochondrial reactive oxygen species induces NLRP3-dependent
lysosomal damage and inflammasome activation. J Immunol 2013;191:5230-8.
182. Gustin A, Kirchmeyer M, Koncina E, Felten P, Losciuto S, et al. NLRP3 inflammasome is expressed and functional in mouse brain
microglia but not in astrocytes. PLoS One 2015;19;10:e0130624.
183. Afonina IS, Zhong Z, Karin M, Beyaert R. Limiting inflammation - the negative regulation of NF-kB and the NLRP3 inflammasome.
Nat Immunol 2017;18:861-9.
184. Elliott EI, Sutterwala FS. Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev 2015;265:35-52.
185. Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 2016;16:407-20.
186. Zambetti LP, Laudisi F, Licandro G, Ricciardi-Castagnoli P, Mortellaro A. The rhapsody of NLRPs: master players of
inflammation...and a lot more. Immunol Res 2012;53:78-90.
187. Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009;27:519-50.
188. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, et al. The pore-forming protein gasdermin D regulates interleukin-1 secretion from living
macrophages. Immunity 2018;48:35-44.e6.
189. Heilig R, Dick MS, Sborgi L, Meunier E, Hiller S, et al. The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice. Eur J
Immunol 2018;48:584-92.
190. Lee HM, Kang J, Lee SJ, Jo EK. Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages
infected with mycobacteria. Glia 2013;61:441-52.
191. Viganò E, Mortellaro A. Caspase-11: the driving factor for noncanonical inflammasomes. Eur J Immunol 2013;43:2240-5.
192. Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, et al. The adaptor ASC has extracellular and ‘prionoid’ activities that
propagate inflammation. Nat Immunol 2014;15:727-37.
193. Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, et al. Microglia-derived ASC specks cross-seed amyloid-β in
Alzheimer’s disease. Nature 2017;552:355-61.
194. Gurung P, Lukens JR, Kanneganti TD. Mitochondria: diversity in the regulation of NLRP3 inflammasome. Trends Mol Med
2015;3:193-201.
195. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome
during apoptosis. Immunity 2012;36:401-14.
196. Nakahira, K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, et al. Autophagy proteins regulate innate immune responses by inhibiting
the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011;12:222-30.
197. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome
activation. Nature 2018;560:198-203.
198. Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011;469:221-5.
199. Bauernfeind F, Bartok E, Rieger A, Franchi L, Núñez G, et al. Cutting edge: reactive oxygen species inhibitors block priming, but not
activation, of the NLRP3 inflammasome. J Immunol 2011;187:613-7.
200. Elliott EI, Miller A, Banoth B, Iyer SS, Stotland A, et al. Cutting edge: mitochondrial assembly of the NLRP3 inflammasome complex
is initiated at priming. J Immunol 2018;200:3047-52.
201. Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, et al. Triggering of inflammasome by aggregated α-synuclein, an
inflammatory response in synucleinopathies. PLoS One 2013;8:e55375.
202. Parajuli B, Sonobe Y, Horiuchi H, Takeuchi H, Mizuno T, et al. Oligomeric amyloid beta induces IL-1beta processing via production
of ROS: implication in Alzheimer’s disease. Cell Death Dis 2013;4:e975.
203. Bellezza I, Grottelli S, Costanzi E, Scarpelli P, Pigna E, et al. Peroxynitrite activates the NLRP3 inflammasome cascade in
SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Mol Neurobiol 2018;55:2350-61.
204. Venegas C, Heneka MT. Inflammasome-mediated innate immunity in Alzheimer’s disease. FASEB J 2019;33:13075-84.
205. Deora V, Lee JD, Albornoz EA, McAlary L, Jagaraj CJ, et al. The microglial NLRP3 inflammasome is activated by amyotrophic
lateral sclerosis proteins. Glia 2020;68:407-21.
206. Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, et al. Transcriptome-based network analysis reveals a spectrum model of human
macrophage activation. Immunity 2014;40:274-88.
207. Healy LM, Yaqubi M, Ludwin S, Antel JP. Species differences in immune-mediated CNS tissue injury and repair: a (neuro)
inflammatory topic. Glia 2020;68:811-29.
208. Stoger JL, Gijbels MJ, van der Velden S, Manca M, van der Loos CM, et al. Distribution of macrophage polarization markers in
human atherosclerosis. Atherosclerosis 2012;225:461-8.
209. Van den Bossche J, O’Neill LA, Menon D. Macrophage immunometabolism: where are we (going)? Trends Immunol 2017;38:395-406.