Page 123 - Read Online
P. 123
Liu et al. Necroptosis and immune dysfunction in ALS
TDP-43 activates microglia through NF-kappaB and NLRP3 familial ALS. Neuron 2014;81:1001-8.
inflammasome. Exp Neurol 2015;273:24-35. 33. Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond
16. Kadhim H, Deltenre P, Martin JJ, Sébire G. In-situ expression of CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han
Interleukin-18 and associated mediators in the human brain of sALS Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli
patients: hypothesis for a role for immune-inflammatory mechanisms. JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR,
Med Hypotheses 2016;86:14-7. McKenna-Yasek D, Cady J, Vianney de Jong JM, Kenna KP, Smith
17. Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer BN, Topp S, Miller J, Gkazi A; FALS Sequencing Consortium, Al-
LP, Hakem R, Caspary T, Mocarski ES. RIP3 mediates the embryonic Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE,
lethality of caspase-8-deficient mice. Nature 2011;471:368-72. Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson
18. Galluzzi L, Vanden Berghe T, Vanlangenakker N, Buettner S, S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider
Eisenberg T, Vandenabeele P, Madeo F, Kroemer G. Programmed NA, Chung WK, Ravits JM, Glass JD, Sims KB, Van Deerlin VM,
necrosis from molecules to health and disease. Int Rev Cell Mol Biol Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F,
2011;289:1-35. Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R,
19. Xiao Y, Li H, Zhang J, Volk A, Zhang S, Wei W, Zhang S, Breslin Harms MB, Cooper GM, Harris T,Myers RM, Goldstein DB. Exome
P, Zhang J. TNF-α/Fas-RIP-1-induced cell death signaling separates sequencing in amyotrophic lateral sclerosis identifies risk genes and
murine hematopoietic stem cells/progenitors into 2 distinct pathways. Science 2015;347:1436-41.
populations. Blood 2011;118:6057-67. 34. Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H,
20. Osborn SL, Diehl G, Han SJ, Xue L, Kurd N, Hsieh K, Cado D, Robey Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez
EA, Winoto A. Fas-associated death domain (FADD) is a negative M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.
regulator of T-cell receptor-mediated necroptosis. Proc Natl Acad Sci RIPK1 mediates axonal degeneration by promoting inflammation and
U S A 2010;107:13034-9. necroptosis in ALS. Science 2016;353:603-8.
21. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. 35. Xin J, Breslin P, Wei W, Li J, Gutierrez R, Cannova J, Ni A, Ng
RIP3, an energy metabolism regulator that switches TNF-induced cell G, Schmidt R, Chen H, Parini V, Kuo PC, Kini AR, Stiff P, Zhu J,
death from apoptosis to necrosis. Science 2009;325:332-6. Zhang J. Necroptosis in spontaneously-mutated hematopoietic cells
22. Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg induces autoimmune bone marrow failure in mice. Haematologica
F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P. The 2017;102:295-307.
Ripoptosome, a signaling platform that assembles in response to 36. Bowerman M, Vincent T, Scamps F, Perrin FE, Camu W, Raoul
genotoxic stress and loss of IAPs. Mol Cell 2011;43:432-48. C. Neuroimmunity dynamics and the development of therapeutic
23. Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, strategies for amyotrophic lateral sclerosis. Front Cell Neurosci
Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M. cIAPs block 2013;7:214.
Ripoptosome formation, a RIP1/caspase-8 containing intracellular 37. Rodrigues MC, Voltarelli JC, Sanberg PR, Borlongan CV, Garbuzova-
cell death complex differentially regulated by cFLIP isoforms. Mol Davis S. Immunological aspects in amyotrophic lateral sclerosis.
Cell 2011;43:449-63. Transl Stroke Res 2012;3:331-40.
24. Vandenabeele P, Melino G. The flick of a switch: which death program 38. Appel SH, Smith RG, Engelhardt JI, Stefani E. Evidence for
to choose? Cell Death Differ 2012;19:1093-5. autoimmunity in amyotrophic lateral sclerosis. J Neurol Sci
25. Christofferson DE, Yuan J. Necroptosis as an alternative form of 1993;118:169-74.
programmed cell death. Curr Opin Cell Biol 2010;22:263-8. 39. Pagani MR, Gonzalez LE, Uchitel OD. Autoimmunity in amyotrophic
26. Upton JW, Kaiser WJ, Mocarski ES. DAI/ZBP1/DLM-1 complexes lateral sclerosis: past and present. Neurol Res Int 2011;2011:497080.
with RIP3 to mediate virus-induced programmed necrosis that 40. Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC. Human
is targeted by murine cytomegalovirus vIRA. Cell Host Microbe embryonic stem cell-derived motor neurons are sensitive to the toxic
2012;11:290-7. effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell
27. Roychowdhury S, McMullen MR, Pisano SG, Liu X, Nagy LE. 2008;3:637-48.
Absence of receptor interacting protein kinase 3 prevents ethanol- 41. Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K. Non-
induced liver injury. Hepatology 2013;57:1773-83. cell autonomous effect of glia on motor neurons in an embryonic stem
28. Linkermann A, Bräsen JH, Darding M, Jin MK, Sanz AB, Heller JO, cell-based ALS model. Nat Neurosci 2007;10:608-14.
De Zen F, Weinlich R, Ortiz A, Walczak H, Weinberg JM, Green DR, 42. Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L,
Kunzendorf U, Krautwald S. Two independent pathways of regulated Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle
necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci U S A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar
A 2013;110:12024-9. BK. Astrocytes from familial and sporadic ALS patients are toxic to
29. Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, motor neurons. Nat Biotechnol 2011;29:824-8.
Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou 43. Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.
W, Amin P, Berlink Lima J, Qi C, Yu Q, Trapp B, Yuan J. Activation Non-cell-autonomous effect of human SOD1 G37R astrocytes on
of necroptosis in multiple sclerosis. Cell Rep 2015;10:1836-49. motor neurons derived from human embryonic stem cells. Cell Stem
30. You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz Cell 2008;3:649-57.
MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves 44. Xiao Q, Zhao W, Beers DR, Yen AA, Xie W, Henkel JS, Appel SH.
functional outcome after controlled cortical impact in mice. J Cereb Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-
Blood Flow Metab 2008;28:1564-73. type microglia. J Neurochem 2007;102:2008-19.
31. Han W, Xie J, Li L, Liu Z, Hu X. Necrostatin-1 reverts shikonin- 45. Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L,
induced necroptosis to apoptosis. Apoptosis 2009;14:674-86. Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich
32. Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz PG, Guttridge DC, Kaspar BK. Microglia induce motor neuron death
B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, via the classical NF-κB pathway in amyotrophic lateral sclerosis.
Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S. Neuron 2014;81:1009-23.
Necroptosis drives motor neuron death in models of both sporadic and 46. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of
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