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Liu et al. Necroptosis and immune dysfunction in ALS

specific inflammation by enhancing angiogenesis and Patient consent
recruiting neutrophil and other innate immune cells and Not applicable.
cause stand-by damage to MNs; (2) interacting with
infiltrating macrophage and/or glial cells (microglial Ethics approval
cells and astrocytes) and initiating an autoimmune Not applicable.
response specifically attacking MN. We think these
two mechanisms may be present at the same time REFERENCES
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There are no conflicts of interest. 15. Zhao W, Beers DR, Bell S, Wang J, Wen S, Baloh RH, Appel SH.
114 Neuroimmunology and Neuroinflammation ¦ Volume 4 ¦ June 16, 2017