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Nwabuobi et al. Thymoma associated panencephalitis

Improvement 1 day after steroids Over 4 weeks after steroids and thymomectomy Improved after initial treatment, with recurrence 3 months later and improvement after removal of thymic met 6 days after thymomectomy and doing fairly well 7 months later MG symptoms improved after IVIG, then seizures improved after thymomectomy; MRI normal 2 years later and patient doing well Improvement in mental status 10 days after thymomectomy a

Treatment Steroids, IVIG, chemotherapy, thymomectomy Steroids, thymomectomy Steroids, PLEX, thymomectomy Thymomectomy IVIG, pyridostigmine Thymomectomy Thymomectomy, steroids, IVIG IVIG, steroids, thymomectomy Thymomectomy, steroids, IVIG, PLEX

Cell surface vs. onconeuronal Ab Cell surface/ onconeuronal - Cell surface - Cell surface Cell surface Cell surface Cell surface Cell surface/ onconeuronal

Antibodies (-) Hu, Ri, Yo, VGCC, NMDA, GABA-B, AMPA, ANNA-3, anti-glial nuclear, PCA-2, PCA- Tr, amphiphysin, AchR (ganglionic neuronal) Hu, Ri, Yo GABA-B, AMPA, NMDA, Caspr2, GlyR, mGLUR5, mGLUR1, GAD AchR VGKC-complex Hu, Ri, Yo - - VGKC-complex, Hu, Ri, Yo, Ma-2, amphiphysin

Table 1: Literature review of cases of thymoma-associated panencephalitis
Antibodies (+) GAD, VGKC- complex, AchR (binding), CRMP5 - GABA-A, LGI1, AchR - AchR AchR AchR, GABA-A, LGI1 LGI1 CRMP5; later AchR

Neurological symptoms Seizures, confusion, agitation, decreased to no verbal response Psychosis, seizures, ocular weakness MG; 8 years later, memory loss, behavioral changes Leg cramping/inability to walk, seizures Seizures, MG (bulbar symptoms) Memory loss, voice change, ptosis, agitation, drowsiness MG; 4 years later, aphasia, seizures, delirium, visual hallucinations Seizures Vertigo, diplopia, nystagmus, left hand

Gender M M F F M F M F M

Age 35 47 45 66 43 42 46 61 32

Year 2016 2015 2015 2013 2013 2012 2011 2009

Paper This case Reginold et al. [11] Simabukuro et al. [12] Aragaki et al. [13] Aysal et al. [14] Suh et al. [15] Miyazaki et al. [16] Erkmen et al. [17] Werry et al. [18]

120 Neuroimmunology and Neuroinflammation ¦ Volume 4 ¦ June 16, 2017