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Chen et al. Neuroimmunol Neuroinflammation 2016;3:274-82 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.21
Neuroinflammation

www.nnjournal.net
Topic: Infectious Disease of Central Nervous System Open Access

Screening of genetic loci predisposing to

herpes simplex virus infection on mouse

chromosome 17

Xiu-Ying Chen , Wei-Ju Tang , Xu-Zheng Zuo , Gong Wang , Hao-Xiang Wang , Peng Xie , Wen Huang 1
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1 Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China.
2 Depatment of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
Correspondence to: Prof. Wen Huang, Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037,
China. E-mail: huang_wen@163.com
How to cite this article: Chen XY, Tang WJ, Zuo XZ, Wang G, Wang HX, Xie P, Huang W. Screening of genetic loci predisposing to herpes
simplex virus infection on mouse chromosome 17. Neuroimmunol Neuroinflammation 2016;3:274-82.
ABSTRACT

Article history: Aim: The herpes simplex virus (HSV), one of the most common viruses infecting humans, is
Received: 24-04-2016 featured by a high infection rate and usually causes complex disorders difficult to diagnose and
Accepted: 02-11-2016 treat. Disease progression is always combined with the specific interaction between organism
Published: 26-12-2016 and environment, but genetic factors play a decisive role in most pathogenic processes. Like
most human disorders, individual difference has also been involved in the pathogenesis
Key words: of HSV infection. The present study aimed to screen the potential gene loci that regulates
Herpes simplex virus, human predisposition to HSV infection. Methods: With reference to previous studies, inbred
susceptibility to infection, mouse lines with significantly distinct predisposition to HSV infection were chosen for gene
microsatellite site, loci screening. Gene sites on mouse chromosome 17 associated with susceptibility to HSV
association analysis, infection were then identified by correlation analysis and genome-wide scanning technique.
mouse chromosome 17 Results: Genes affecting the vulnerability of mice to HSV infection were mapped to three
regions on the 17th mouse chromosome, D17MIT51.1, D17MIT39.1 and the region between
D17MIT180.1 and D17MIT184. Conclusion: The results suggest that the mouse genetic
background plays an important role in its susceptibility to HSV-1 infection, which might be
regulated by multiple predisposing quantitative trait loci.

INTRODUCTION HSV infection in mice have been long studied. Several
reports related to HSV infection susceptibility further
As an infection relapse could confer severe pointed to the role of genetic background in the HSV
consequence in the pathogenicity of herpes simplex infection process. [1-5] To further analyze the susceptibility
virus (HSV) infection, avoiding infection and preventing to HSV infection in different inbred mouse lines, we
recurrence after treatment is of great importance. scanned the 17th mouse chromosome for gene sites
Individual differences involved in the pathogenesis of associated with it using the correlation analysis and

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